鱼腥草芩蓝合剂治疗小儿急性扁桃体炎的临床效果

Clinical Effect of Yuxingcao Qinlan Mixture in the Treatment of Acute Tonsillitis in Children

目的:探讨鱼腥草芩蓝合剂治疗小儿急性扁桃体炎的临床效果。方法:选取2020年3月—2022年3月山西医科大学第一医院儿科收治的96例急性扁桃体炎患儿作为研究对象。随机分为对照组(n=48)和观察组(n=48)。对照组给予常规对症治疗,观察组在对照组基础上给予鱼腥草芩蓝合剂治疗。比较两组时间指标,治疗前后炎症因子、免疫功能,不良反应及临床疗效。结果:观察组鼻塞消退时间、咳嗽消退时间、扁桃体充血消退时间、扁桃体脓点消退时间、退热时间均明显早于对照组,差异有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及C反应蛋白(CRP)水平均降低,观察组TNF-α、CRP及IL-6水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD8^(+)降低,CD4^(+)和CD4^(+)/CD8^(+)升高,观察组CD8^(+)低于对照组,CD4^(+)和CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:鱼腥草芩蓝合剂可改善小儿急性扁桃体炎临床症状,减轻炎症反应,提高免疫力,安全性和疗效均较好。

Objective:To explore the clinical effect of Yuxingcao Qinlan Mixture in the treatment of acute tonsillitis in children.Method:A total of 96 children with acute tonsillitis treated in the Department of Pediatrics of the First Hospital of Shanxi Medical University from March 2020 to March 2022 were selected as the study objects.Randomly divide into control group(n=48)and observation group(n=48).The control group was given conventional symptomatic treatment,and the observation group was given Yuxingcao Qinlan Mixture on the basis of the control group.Time indexes,inflammatory factors,immune function before and after treatment,adverse reactions and clinical efficacy were compared between the two groups.Result:Nasal congestion resolution time,cough resolution time,tonsil congestion resolution time,tonsil pus spot resolution time and fever resolution time in observation group were significantly earlier than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factorα(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)were decreased in both groups,and the levels of TNF-α,CRP and IL-6 in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,CD8^(+)decreased in both groups,and CD4^(+)and CD4^(+)/CD8^(+)increased in both groups,CD8^(+)in the observation group was lower than that in the control group,and CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Yuxingcao Qinlan Mixture can improve the clinical symptoms of acute tonsillitis in children,reduce inflammation reaction,improve immunity,safety and efficacy are good.