HbA1c、LDL-C、HDL-C联合检测在2型糖尿病肾病中的诊断价值

Diagnostic Value of HbA1c,LDL-C and HDL-C Combined Detection in Type 2 Diabetic Nephropathy

目的:探究糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)联合检测在2型糖尿病肾病中的诊断价值。方法:选取2019年1月—2021年12月南京中医药大学附属苏州市中医医院收治的120例2型糖尿病患者作为研究对象。根据患者是否发生糖尿病肾病将其分为合并肾病组(n=35)和未合并肾病组(n=85)。收集两组患者一般资料。检测两组Hb A1c、LDL-C、HDL-C。比较两组一般资料及Hb A1c、LDL-C、HDL-C水平。分析2型糖尿病肾病的危险因素。分析HbA1c、LDL-C、HDL-C对2型糖尿病肾病的诊断价值。结果:合并肾病组糖尿病病程长于未合并肾病组,吸烟史占比高于未合并肾病组,差异有统计学意义(P<0.05)。合并肾病组HbA1c、LDL-C水平均高于未合并肾病组,HDL-C水平低于未合并肾病组,差异有统计学意义(P<0.05)。logistic分析结果显示,HbA1c、LDL-C、吸烟史、糖尿病病程均是2型糖尿病患者合并糖尿病肾病的危险因素,HDL-C是保护因素(P<0.05)。HbA1c、LDL-C、HDL-C联合检测的AUC最高。结论:HbA1c、LDL-C、HDL-C联合检测应用于2型糖尿病肾病诊断中,具有较高的诊断价值,为临床对2型糖尿病肾病的早期诊断提供新思路。

Objective:To explore the diagnostic value of glycated hemoglobin(HbA1c),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)combined detection in type 2 diabetic nephropathy.Method:A total of 120 patients with type 2 diabetes admitted to Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine from January 2019 to December 2021 were selected as the study objects.According to whether the patients had diabetic nephropathy,they were divided into the group with nephropathy(n=35)and the group without nephropathy(n=85).General data of the two groups were collected.HbA1c,LDL-C and HDL-C were detected in both groups.General data and levels of HbA1c,LDL-C and HDL-C were compared between the two groups.The risk factors of type 2 diabetic nephropathy was analyzed.The diagnostic value of HbA1c,LDL-C and HDL-C in type 2 diabetic nephropathy was analyzed.Result:The duration of diabetes in the group with nephropathy was longer that in the group without nephropathy,and the proportion of smoking history was higher than that in the group without nephropathy,the differences were statistically significant(P<0.05).The levels of HbA1c and LDL-C in the group with nephropathy were higher than those in the group without nephropathy,the HDL-C level was lower than that in the group without nephropathy,the differences were statistically significant(P<0.05).logistic analysis results showed that HbA1c,LDL-C,smoking history,and duration of diabetes were all risk factors for type 2 diabetic patients with diabetic nephropathy,and HDL-C was the protective factor(P<0.05).The highest AUC was detected by combining HbA1c,LDL-C,and HDL-C.Conclusion:The combined detection of HbA1c,LDL-C and HDL-C has high diagnostic value in the diagnosis of type 2 diabetic nephropathy,and provides a new idea for the early diagnosis of type 2 diabetic nephropathy.