急性脑血管病患者病情严重程度对免疫功能的影响

Effect of Disease Severity on Immune Function in Patients with Acute Cerebrovascular Disease

目的:探讨急性脑血管病患者病情严重程度对免疫功能的影响。方法:选择2021年2月—2023年1月苏州大学附属常州老年病医院收治的106例急性脑血管病患者作为研究对象,依据格拉斯哥昏迷评分法(GCS)评估患者病情严重程度(总分3~15分),将其分为轻型组(13~15分,n=36)、中型组(9~12分,n=35)、重型组(3~8分,n=35)。三组均行血清免疫功能指标检测,并对比各指标差异。结果:轻型组免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平显著高于中型组和重型组,中型组显著高于重型组,差异有统计学意义(P<0.05);轻型组、补体C3(C3)、补体C4(C4)水平显著低于中型组和重型组,中型组显著低于重型组,差异有统计学意义(P<0.05)。轻型组CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平显著高于中型组和重型组,中型组显著高于重型组,差异有统计学意义(P<0.05);轻型组CD8^(+)水平显著低于中型组和重型组,中型组显著低于重型组,差异有统计学意义(P<0.05)。结论:急性脑血管病患者存在免疫功能下降表现,中型、重型患者免疫功能较轻症患者下降显著,随病情加重,免疫功能抑制越显著。

Objective:To investigate the effect of disease severity on immune function in patients with acute cerebrovascular disease.Method:A total of 106 patients with acute cerebrovascular disease who admitted to Changzhou Geriatric Hospital Affiliated to Soochow University from February 2021 to January 2023 were selected as the research objects,according to the Glasgow coma scale(GCS)was evaluated the severity of patients(total score 3-15 points),they were divided into mild group(13-15 points,n=36),moderate group(9-12 points,n=35),and severe group(3-8 points,n=35).The serum immune function indexes were detected among three groups,and the differences of each index were compared.Result:The levels of immunoglobulin M(IgM),immunoglobulin A(IgA)and immunoglobulin G(IgG)in the mild group were significantly higher than those in the moderate group and the severe group,and which in the moderate group were significantly higher than those in the severe group,the differences were statistically significant(P<0.05);the levels of complement C3(C3)and complement C4(C4)in the mild group were significantly lower than those in the moderate group and the severe group,and which in the moderate group were significantly lower than those in the severe group,the differences were statistically significant(P<0.05).The levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the mild group were significantly higher than those in the moderate group and the severe group,and which in the moderate group were significantly higher than those in the severe group,the differences were statistically significant(P<0.05);the level of CD8^(+)in the mild group was significantly lower than those in the moderate group and the severe group,and that in the moderate group was significantly lower than that in the severe group,the differences were statistically significant(P<0.05).Conclusion:Patients with acute cerebrovascular disease have decreased immune function,the immune function of patients with moderate and severe disease are significantly lower than those of patients with mild disease,with the aggravation of disease,the inhibition of immune function is more significant.