中药治疗肝肾亏虚型膝骨关节炎的用药规律研究

Study on the Medication Regularity of Traditional Chinese Medicine in Treating Knee Osteoarthritis of Liver and Kidney Deficiency Type

目的:基于数据挖掘技术探究运用中药复方治疗肝肾亏虚型膝骨关节炎(KOA)的组方用药规律。方法:通过检索中国知网(CNKI)数据库中内服中药治疗肝肾亏虚型KOA的文献,筛选出符合纳入排除标准的方药内容录入Excel2019进行整理统计,使用SPSS Modeler 18.0进行关联规则分析,SPSS Statistics 26.0进行聚类分析。结果:纳入文献共62篇,涉及中药134味,使用频次≥13的药物共18味;前五位高频中药为牛膝、当归、熟地黄、杜仲、甘草;药物性味以甘温为主,归经多为肝、肾经。通过关联规则分析得到115条结果,其中两项关联支持度最高的为当归-牛膝;三项关联支持度最高的为白芍-当归-牛膝;四项关联支持度最高的为甘草-当归-牛膝-川芎。通过聚类分析将高频药物分成三类,第一类为秦艽、细辛、防风、川芎、独活、党参、桑寄生、茯苓、甘草、当归、白芍、生地黄;第二类为山茱萸、枸杞子、淫羊藿;第三类为熟地黄、杜仲、牛膝。结论:通过口服中药的方法治疗肝肾亏虚型KOA时,应以补益肝肾、活血化瘀为主,根据临床症状表现适当辅以祛风除湿、补益气血、收敛固涩的药物。

Objective:To explore the medication regularity in the treatment of knee osteoarthritis(KOA)with liver and kidney deficiency based on the data mining technology.Method:By searching the literature on the treatment of liver and kidney deficiency type KOA with traditional Chinese medicine in the China national knowledge infrastructure(CNKI)database,and selected the prescription content that met the inclusion and exclusion criteria and entered it into Excel 2019 for sorting and statistics.SPSS Modeler 18.0 was used for association rule analysis,and SPSS Statistics 26.0 was used for cluster analysis.Result:A total of 62 articles were included,involving 134 traditional Chinese medicines and a total of 18 drugs with a frequency of use≥13;the top five high-frequency traditional Chinese medicines were Niuxi,Danggui,Shudihuag,Duzhong,and Gancao;the medicinal taste was mainly sweet and warm,with the liver and kidney meridians being the main meridians.A total of 115 results were obtained through association rule analysis,with the highest support for two associations being Danggui-Niuxi;the highest support for the three associations was Baishao-Danggui-Niuxi;the highest support for the four associations was Gancao-Danggui-Niuxi-Chuanxiong.By clustering analysis,high-frequency drugs were divided into three categories.The first category were Qinjiao,Xixin,Fangfeng,Chuanxiong,Duhuo,Dangshen,Sangjisheng,Fuling,Gancao,Danggui,Baishao,Shengdihuang;the second type were Shanzhuyu,Gouqizi,Yinyanghuo;the third type were Shudihuang,Duzhong,Niuxi.Conclusion:When treating liver and kidney deficiency type KOA through oral administration of traditional Chinese medicine,the main focus should be on tonifying the liver and kidney,promoting blood circulation and removing blood stasis.According to clinical symptoms,appropriate medications such as dispelling wind and dampness,supplementing Qi and blood,convergence and astringent should be supplemented.