摘要
Interleukin-6(IL-6)is a common pluripotent cytokine that is highly expressed in the tumor microenvironment.The IL-6/JAK/STAT3 signaling directly promotes tumor progression,severely hampering antitumor immunity.Macrophages,the richest innate immune cells within the tumor microenvironment,manipulate tumor progression via phenotypic plasticity.
基金
supported by the Shandong Province Major Scientific and Technological Innovation Project(China)(No.2020CXGC010503)
the Shandong Provincial Key Laboratory Platform Project(China)(No.2021ZDSYS11)
the National Natural Science Foundation of China Major Project(No.81991525).
