牛白藤化学成分、药理作用及临床应用研究

Research on chemical composition and pharmacological effects and clinical application of Hedyotis hedyotidea(DC.)Merr.

牛白藤[Hedyotis hedyotidea(DC.)Merr.]为茜草科耳草属干燥全草,在我国广西、广东、福建、台湾地区、贵州、云南等地广泛分布,资源丰富。现代研究表明,牛白藤中含有萜类、甾体类、香豆素类、木脂素类等化合物,具有镇痛、抗肿瘤、抗菌消炎、抗白血病效应等作用。目前,牛白藤的药理活性研究大多以萜类为主,但是相关的药理机制研究较少。因此,本文对牛白藤的化学成分与药理作用及临床应用研究进行归纳总结,为今后对牛白藤的开发利用提供理论参考。

Hedyotis hedyotidea(DC.)Merr.is a dried whole grass of the genus Rubiaceae.It has abundant resources and is widely distributed in Guangxi,Guangdong,Fujian,Taiwan region,Guizhou,Yunnan and other places in China.Modern research shows that Hedyotis hedyotidea(DC.)Merr.contains terpenes,steroids,coumarins,lignans and other compounds.It has analgesic,antitumor,antibacterial,anti-inflammatory,anti-leukemia effects and other effects.At present,most of the pharmacological activity studies of Hedyotis hedyotidea(DC.)Merr.are mainly on terpenes,but there are few studies on related pharmacological mechanisms.Therefore,this paper summarized the chemical composition,pharmacological effects and clinical application research of Hedyotis hedyotidea(DC.)Merr.,in order to provide a theoretical reference for the development and utilization of Hedyotis hedyotidea(DC.)Merr.in the future.