克唑替尼相关性肾囊肿1例

A case of crizotinib-associated renal cysts

克唑替尼相关性肾囊肿(CARC)是指在使用克唑替尼治疗后新发肾囊肿或先前存在的肾囊肿发生变化,停用克唑替尼后,大多数CARC会自行消退。少数CARC表现出侵袭性行为,可超过肾皮质侵入附近结构,包括肾周间隙、腰大肌、肠道和腹壁等。本文报道了1例浸润性肺腺癌EML4-ALK融合突变,给予克唑替尼治疗后反复出现双肾、右侧竖直肌、腰大肌多发囊性改变,停用药物后自行吸收消退过程。

Crizotinib-associated renal cysts(CARC)are the development of new renal cysts or pre-existing renal cysts after the treatment with crizotinib.Most CARC disappear after crizotinib is stopped.A few CARC showed aggressive behavior that could go beyond the invasion of the renal cortex into nearby structures,including perirenal space,psoas major muscle,intestine,and abdominal wall.A case of EML4-ALK fusion mutation in invasive lung adenocarcinoma has been reported.Multiple cystic changes occurred repeatedly in both kidneys,right rectus muscle,and psoas major muscle after treatment with crizotinib,and spontaneous absorption and resolution after discontinuation of the drug.