抗体免疫缺陷病成年患者的呼吸系统表现

Primary antibody deficiencies and respiratory manifestations in adults

抗体免疫缺陷病是一组由遗传缺陷引起的先天性疾病,影响机体免疫防御机制的发育和功能。患者可表现为反复感染、淋巴细胞增殖、自身免疫性疾病、自身炎症或恶性肿瘤。呼吸系统可表现为支气管扩张症、支气管哮喘、间质性肺疾病等。深入了解抗体免疫缺陷病将有助于将其从呼吸系统常见疾病中甄别出来。

Primary antibody deficiencies(PAD)are a group of congenital disorders caused by genetic defects that affect the development and function of the body′s immune defence mechanisms.Patients with PAD may present with recurrent infections,lymphoproliferation,autoimmune diseases,autoinflammation,or malignancies.Respiratory system manifestations may include bronchiectasis,bronchial asthma,and interstitial lung disease,among others.A comprehensive understanding of PADs will help to distinguish these covert cases from more common respiratory diseases.