天然化合物基于Notch通路抑制肿瘤的研究进展

Research progress on natural compounds inhibiting tumors via Notch pathway

恶性肿瘤是威胁人类健康的全球疾病负担,我国恶性肿瘤新发病例和新发癌症死亡病例均位居全球首位,因此抗肿瘤药物的开发备受关注。Notch信号通路广泛存在于人体各种器官,是影响肿瘤发生与发展的关键信号传导途径之一,关系到肿瘤细胞的多种受体与细胞功能。该信号通路机制复杂,出现异常的激活或阻断将会导致机体紊乱,引起恶性肿瘤的发生。我国植物种类丰富多样,其中不乏食品药品资源,来源植物的天然化合物由于其对于癌症治疗具有积极影响,更是成为近年来抗肿瘤研究及药物开发的热点。已有大量研究表明,天然化合物能够通过靶向Notch通路对多种肿瘤发挥抑制作用。本文就Notch通路与肿瘤的关系、天然化合物基于Notch信号对抗肿瘤的作用机制研究现状进行归纳综述,并对其未来的研究方向进行了展望,旨在为靶向Notch的抗肿瘤药物开发以及植物资源的利用提供理论参考与科学思路。

Malignant tumor is a global disease burden threatening human health,and the new cases of malignant tumor and new cancer deaths in China rank first in the globe,so development of anti-tumor drugs has attracted much attention.Notch signaling pathway is widely found in various organs of human body,and is one of the key signaling pathways affecting the occurrence and development of tumors,which is related to a variety of receptors and cell functions of tumor cells.The mechanism of this signaling pathway is complex,and abnormal activation or blocking of Notch will lead to the disorder of the body,causing the occurrence of malignant tumors.There are many kinds of plants in China,including food and drug resources.Natural compounds derived from plants have become a hot spot of anti-tumor studies and drug development in recent years because of their positive effects on cancer treatment.Numerous studies have demonstrated that natural compounds could exert inhibitory effects on various tumors by targeting the Notch pathway.This review summarized the relationship between Notch pathway and tumors and studied on the anti-tumor activity and mechanism of natural compounds via Notch pathway.Furthermore,this paper outlined potential future research directions in the field,in order to provide theoretical references and scientific ideas for development of anti-tumor drugs targeting Notch and utilization of plant resources.