牙源性干细胞来源的外泌体在牙周组织再生中的研究进展

Advancement of Dental Stem Cells-derived Exosomes in Periodontal Tissue Regeneration

牙周炎是影响我国人群健康和生活质量的常见口腔疾病。实现满意的牙周组织结构与功能的再生,以保留更多天然牙是目前治疗牙周炎的目标。外泌体是一种内含多种生物活性物质的纳米级囊泡,经摄取可以参与细胞间信息交流与物质交换。牙源性干细胞独特的组织特异性,使其来源的外泌体在牙周组织再生方面成为热点之一。本文就牙源性干细胞来源的外泌体在牙周组织再生中研究新进展作一综述,以期为牙周炎相关研究提供新思路。

Periodontitis is a common oral disease affecting the health and quality of life.Achieving satisfactory regeneration of periodontal tissue structure and function to preserve more teeth is the goal of treatment.Exosomes are nano vesicles containing a variety of biologically active substances,which can participate in intercellular information exchange and material transfer upon cellular uptake.The unique tissue specificity of dental stem cells makes the exosomes derived from them one of the hot spots in periodontal tissue regeneration.This paper reviews the latest progress of exosomes derived from dental stem cells in periodontal tissue regeneration,with a view to provide new ideas for periodontitis-related research.