肝动脉栓塞联合超声下射频消融术治疗原发性肝癌患者的临床疗效

Clinical efficacy of TACE combined with ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer

目的 探究肝动脉栓塞(TACE)联合超声引导下射频消融术对原发性肝癌患者临床疗效及肝功能的影响。方法 选取2019年5月1日至2021年6月30日入我院首次治疗的原发性肝癌患者100例,随机分为对照组和观察组,对照组为TACE单纯治疗方案患者50例,观察组为TACE联合超声下经皮射频消融术治疗患者50例。比较两组肝功能情况、临床疗效、生存情况及并发症。结果 治疗后观察组ALT、AST、TBiL水平及AFP水平较对照组显著降低;观察组近期临床疗效总有效率为76%,较对照组的48%,差异有统计学意义(χ^(2)=8.319,P=0.004);观察组无进展生存时间(12.13±2.95)月,对照组(9.05±3.73)月,差异有统计学意义(t=3.237,P<0.05);观察组1年生存率(90%)高于对照组(58%),差异有统计学意义(χ^(2)=13.306,P<0.05)。观察组并发症发生率高于对照组(χ^(2)=4.456,P=0.035)。结论 TACE联合超声引导下射频消融术治疗原发性肝癌,具有显著的临床疗效,可在一定程度上改善肝功能,具有广泛、良好的临床应用前景。

Objective To investigate the effect of transcatheter arterial chemoembolization(TACE) combined with ultrasound-guided percutaneous radiofrequency ablation and hepatic arterial embolization(TACE) on clinical efficacy and liver function in patients with primary liver cancer.Methods A total of 100 patients with primary liver cancer admitted to our hospital from May 2019 to June 2021 were randomly divided into two groups:control group and Observation Group.Fifty patients with primary liver cancer were treated with TACE only in the control group,and the other 50 patients were treated in the Observation Group,that was treated with ultrasound guided percutaneous radiofrequency ablation and TACE.The liver function,clinical efficacy,adverse reaction and survival rate were compared between the two groups.Results After treatment,the levels of ALT,AST,total bilirubin and AFP in the observation group were significantly lower than those in the control group,and the short-term effective rate was 76% in the Observation Group,48% in the control group,and the difference was significant(χ^(2)=8.319,P=0.004);the progression-free survival time was(12.13±2.95) months in the observation group and(9.05±3.73) months in the control group,and the difference was significant(t=3.237,P<0.05).The 1-year survival rate of the observation group(90%) was higher than that of the control group(58%),the difference was statistically significant(χ^(2)=13.306,P<0.05).The incidence of complications in the observation group was higher than in the control group(χ^(2)=4.456,P=0.035).Conclusion TACE combined with ultrasound-guided percutaneous radiofrequency ablation in the treatment of primary liver cancer has a significant clinical effect,can improve liver function to a certain extent,and has a broad and good clinical application prospect.