供体与受体年龄差距和供肝重量与受体体重比值对肝移植术后伤口感染的影响

Influence of donor-recipient age gap and donor liver weight to recipient weight ratio on wound infection after liver transplantation

目的探讨供体与受体年龄差距和供肝重量与受体体重比值对受体术后伤口感染的影响。方法回顾性收集2017年6月1日至2023年9月1日在武汉大学人民医院行肝移植手术患者的临床资料。通过卡方检验分析组间倾向性匹配评分前和倾向性匹配评分后受体伤口感染率的差异。结果供体受体年龄差距大于等于10岁共32例。51例供体和受体年龄差距小于10岁。倾向性匹配评分前:早期感染率无差异,晚期感染率无差异。46例供肝重量与受体体重的比值大于0.01,37例供肝重量与受体体重的比值小于等于0.01。倾向性匹配评分前:早期感染率无差异,晚期感染率无差异。32例供体受体年龄差距大于等于10岁,按照1∶1匹配了32例供体和受体年龄差距小于10岁的患者。倾向性匹配评分后:早期感染率有统计学差异(χ^(2)=4.27,P=0.04),晚期感染率无差异。37例供肝重量与受体体重的比值小于等于0.01。按照1:1匹配了37例供肝重量与受体体重的比值大于0.01的患者。倾向性匹配评分后:早期感染率有统计学差异(χ^(2)=9.95,P<0.01),晚期感染率无差异。结论供体与受体年龄差距大于等于10岁和供体肝重量与受体体重的比值小于等于0.01是受体术后早期伤口感染的危险因素。

Objective Examining the effects of donor-recipient age gap and donor liver weight-torecipient weight ratio on postoperative wound infection in recipients.Methods Clinical data of patients undergoing liver transplantation at Renmin Hospital of Wuhan University from June 1,2017 to September 1,2023 were retrospectively collected.Differences in donor infection rates between groups before and after propensity scoring were analyzed by chi-square test.Results The donor-recipient age gap was greater than or equal to 10 years in 32 cases.A total number of 51 cases had a donor-recipient age gap less than 10 years.Pre-propensity score:no difference in early infection rate.Late infection rate did not differ.The ratio of donor liver weight to recipient body weight was greater than 0.01 in 46 cases.The ratio of donor liver weight to recipient body weight was less than or equal to 0.01 in 37 cases.Before propensity scoring:early infection rate did not differ.Late infection rate did not differ.A total number of 32 donor-recipients had an age difference greater than or equal to 10 years.Thirtytwo patients with a donor-recipient age gap less than 10 years were matched according to 1∶1.After propensity scoring:early infection rates were statistically different(χ^(2)=4.27,P=0.04).There was no difference in the rate of late infection.A total number of 37 patients have a donor liver weight-to-recipient weight ratio less than or equal to 0.01.A total number of 37 patients with a donor weight-to-recipient weight ratio greater than 0.01 were matched according to a 1∶1 ratio.After propensity scoring:early infection rates were statistically different(χ^(2)=9.95,P<0.01).There was no difference in the late infection rate.Conclusion Donor-recipient age greater than 10 years and donor liver weight to recipient body weight ratio less than or equal to 0.01 were risk factors for early postoperative wound infection in recipients.