摘要
To the Editor:G protein-coupled receptors(GPCRs)are the largest group of membrane proteins with over 800 members,characteristic of a seven transmembrane domain1.By playing crucial roles in regulation of various physiological processes,GPCRs have been implicated in many diseases including diabetes,obesity,depression and cancer.To initiate different intracellular responses,GPCRs mainly interact with three families of effector proteins upon agonist binding:the heterotrimeric G proteins,G protein-coupled receptor kinases(GRKs)and arrestins1.
基金
supported by the National Natural Science Foundation of China 82273961(Ming-Wei Wang),82073904(MingWei Wang),81872915(Ming-Wei Wang),82273985(Dehua Yang)and 81973373(Dehua Yang)
Shanghai Municipality Science and Technology Development Fund 21JC1401600(Dehua Yang)and 23XD1400900(Dehua Yang)
National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(Ming-Wei Wang)and 2018ZX097110002-002-005(Dehua Yang)
STI2030-Major Project 2021ZD0203400(Qingtong Zhou)
the National Key Basic Research Program of China 2018YFA0507000(Ming-Wei Wang)
Hainan Provincial Major Science and Technology Project ZDKJ2021028(Dehua Yang and Qingtong Zhou)。
