五肽重复蛋白的结构和功能研究进展

Advances in the structural and functional study of pentapeptide repeat proteins

五肽重复蛋白(pentapeptide repeat proteins,PRPs)是一类超家族蛋白,在近3500个物种中有超过38000个序列,大多数属于蓝藻,但在生命的所有分支中都有分布,PRPs在不同物种中功能各异,在生物体内涉及到多个生物学过程。本文主要对PRPs的五肽重复序列、三维结构以及相关功能的特点进行总结,旨在阐述PRPs的蛋白结构特征以及在不同物种中相关的生理功能,为后续PRPs的深入研究提供重要的理论依据。

The pentapeptide repeat proteins(PRPs)are a large superfamily with over 38000 sequences in nearly 3500 species,mostly belonging to cyanobacteria but distributed in all branches of life.PRPs have different functions in different species and are involved in several biological processes in living organisms.In this paper,we mainly summarize the characteristics of PRPs,three-dimensional structures and related functions of PRPs,aiming to elucidate the protein structures and related physiological functions of PRPs in different organisms and provide an important theoretical basis for the subsequent in-depth study of PRPs.