大连地区10818例健康体检女性人乳头瘤病毒感染特征分析

An Analysis of Characteristics of HPV Infection in 10818 Healthy Examined Women in Dalian Area

目的探讨大连地区体检女性人乳头瘤病毒(human papillomavirus,HPV)感染型别及分布特征,为宫颈癌防治提供有效的流行病学依据。方法收集2023年1月至2024年1月大连大学附属中山医院的女性健康体检者样本10818例,采用DNA芯片技术对23种HPV分型进行检测,并比较不同年龄段人群感染情况和基因分型差异。结果10818例样本中HPV阳性率为9.69%(1048/10818),HPV亚型中阳性率最高的5种型别分别为HPV16(1.80%,195/10818)、HPV53(1.59%,172/10818)、HPV52(1.20%,1300/10818)、HPV81(1.15%,124/10818),HPV56(0.81%,88/10818)。不同年龄段间阳性率差异具有统计学意义(χ^(2)=24.494,P<0.01),其中≥60岁组HPV阳性率最高(14.60%,79/541),其次为25~29岁组(13.07%,63/482),30~34岁组HPV阳性率最低(8.78%,157/1788)。在HPV阳性患者中,单一亚型感染占75.29%(789/1048),多重亚型感染占24.71%(259/1048)。各年龄组HPV感染均以单一感染为主,其次为双重感染,构成比差异不具有统计学意义(χ^(2)=9.630,P>0.05)。结论辽宁省大连市健康体检女性HPV阳性率为9.69%,高危型HPV16、HPV53、HPV52、HPV56和低危型HPV81是最常见的5种感染亚型。各年龄组均以单一高危型感染为主。≥60岁组HPV阳性率最高,应高度关注。

Objective This study aimed to investigate the type and distribution of human papillomavirus(HPV)infection in women undergoing physical examination in Dalian area.The findings can be used as an epidemiological basis for preventing and treating cervical cancer.Methods 10818 female health checkups were collected from Zhongshan Hospital of Dalian University between January,2023 and January,2024.DNA microarray technology was used to detect 23 HPV subtypes and to compare the infections and genotyping differences among various age groups.Results The HPV positivity rate among the 10818 samples was 9.69%(1048/10818),and the five HPV subtypes with the highest positivity rates were HPV16(1.80%,195/10818),HPV53(1.59%,172/10818),HPV52(1.20%,1300/10818),HPV81(1.15%,124/10818),and HPV56(0.81%,88/10818).The difference in positivity rates between different age groups was statistically significant(χ^(2)=24.494,P<0.01),with the highest HPV positivity rate in the≥60 group(14.60%,79/541),followed by the 25 to 29-year-old group(13.07%,63/482),and the lowest HPV positivity rate in the 30 to 34-year-old group(8.78%,157/1788).Among HPV-positive patients,75.29%(789/1048)were infected with a single subtype and 24.71%(259/1048)were infected with multiple subtypes.HPV infections in all age groups were dominated by single infections,followed by dual infections,and the difference in the composition ratio was not statistically significant(χ^(2)=9.630,P>0.05).Conclusion During physical examinations of healthy women in Dalian area,Liaoning Province,we show that the HPV positivity rate is 9.69%.The five most common infection subtypes are high-risk HPV16,HPV53,HPV52,HPV56,and low-risk HPV81.One predominant high-risk type of infection is found in all age groups.The group of women aged 60 and above has the highest rate of HPV positivity and need to be closely monitored.