HIV患者抗病毒治疗前后体内Hcy、免疫球蛋白、β_(2)微球蛋白等指标的变化分析

An Analysis of Changes of Hcy,Immunoglobulin,β_(2) Microglobulin and Other Indicators in HIV Patients Before and After Antiviral Treatment

目的探究HIV患者抗病毒治疗前后体内同型半胱氨酸(Hcy)、免疫球蛋白G(IgG)和β_(2)微球蛋白(β_(2)-MG)等指标的变化分析。方法选取我院进行检查并住院进行抗病毒治疗的87例HIV患者(2019年1月至2020年5月)作为研究目标。通过分析初诊时和治疗后患者血清中Hcy、β_(2)-MG表达水平、免疫球蛋白表达水平、γ-GT、LACT表达水平、T细胞亚群的差异性来探究HIV感染患者抗病毒治疗前后体内同型半胱氨酸(Hcy)、免疫球蛋白G(IgG)和β_(2)微球蛋白(β_(2)-MG)等指标的变化分析。结果初诊时和治疗后相比较,初诊时患者免疫球蛋白表达水平显著高于治疗后(P<0.05)。初诊时患者T细胞亚群CD3、CD4、CD8表达分别为(53.84±6.47)%、(33.52±3.65)%、(23.67±2.82)%,治疗后患者体内CD3、CD4、CD8表达分别为(64.65±6.42)%、(2.31±4.83)%、(27.78±3.89)%,初诊时患者T细胞亚群表达水平低于治疗后(P<0.05),CD4^(+)/CD8^(+)比值相差较小(P>0.05)。初诊时和治疗后相比较,初诊时患者Hcy、β_(2)-MG表达水平明显高于治疗后(P<0.05)。初诊时患者γ-GT、LACT表达分别为112.65±21.14U/L、4.35±1.28mmol/L,治疗后患者体内γ-GT、LACT表达分别为140.72±32.25U/L、1.33±0.27mmol/L,初诊时患者LACT表达水平明显高于治疗后(P<0.05),而初诊时患者γ-GT表达水平低于治疗后(P<0.05)。结论HIV感染患者抗病毒治疗后体内T细胞亚群、免疫球蛋白表达水平等免疫指标均出现显著改变,同时,Hcy、β_(2)-MG、LACT表达水平明显下降,γ-GT表达水平显著上升,因此,在临床研究中,可以通过检测上述指标进行艾滋病患者的诊断及治疗,建议推广使用。

Objective To explore changes of homocysteine(Hcy),immunoglobulin G(IgG)andβ_(2) microglobulin(β_(2)-MG)in HIV-infected patients before and after antiviral treatment.Methods 87 HIV patients(from Jan.2019.to May 2020)who were examined and hospitalized for antiviral treatment in our hospital were selected as the research subjects.By analyzing the differences in serum Hcy,β_(2)-MG expression levels,immunoglobulin expression,γ-GT,LACT expression levels,and T cell subsets in patients at the time of initial diagnosis and after treatment,we studied the homotype and half of HIV-infected patients before and after antiviral treatment.We conducted analysis of changes in indicators,such as cystine(Hcy),immunoglobulin G(IgG)and β_(2) microglobulin(β_(2)-MG).Results Compared with the first diagnosis and after treatment,the expression level of immunoglobulin in the first diagnosis was significantly higher than that after treatment(P<0.05).Expressions of T cell subsets CD3,CD4,CD8 of patients at the first diagnosis were(53.84±6.47)%,(33.52±3.65)%,(23.67±2.82)%,and expressions of CD3,CD4,and CD8 were(64.65±6.42)%,(42.31±4.83)%,(27.78±3.89)%after treatment.The expression level of T cell subsets was lower than that after treatment(P<0.05),and the difference in the ratio of CD4^(+)/CD8^(+)was small(P>0.05).Compared with the first diagnosis and after treatment,expression levels of Hcy andβ_(2)-MG in the first diagnosis were significantly higher than those after treatment(P<0.05).The expressions ofγ-GT and LACT were 112.65±21.14U/L and 4.35±1.28mmol/L at the time of initial diagnosis.After treatment,expressions ofγ-GT and LACT were 140.72±32.25U/L and 1.33±0.27mmol/L,respectively.The expression level of LACT at the first diagnosis was significantly higher than that after treatment(P<0.05),while the expression level ofγ-GT at the first diagnosis was lower than that after treatment(P<0.05).Conclusion After antiviral treatment of HIV-infected patients,immune indicators,such as T cell subsets and immunoglobulin expression levels,are significantly changed.At the same time,expression levels of Hcy,β_(2)-MG,and LACT are decreased significantly,and the expression level ofγ-GT is increased significantly.Therefore,in clinical research,the above indicators can be used to diagnose and treat AIDS patients,and it is recommended to promote its application.