针刺联合孟鲁司特钠治疗支气管哮喘的疗效观察及对气道阻力的影响

Therapeutic observation of acupuncture plus Montelukast sodium for bronchial asthma and the effect on airway resistance

目的观察针刺肺经及大肠经腧穴联合孟鲁司特钠治疗支气管哮喘的临床疗效及其对患者气道阻力和血清α1-酸性糖蛋白(α1-acid glycoprotein,α1-AG)水平的影响。方法选取136例支气管哮喘患者,按照随机数字表法分为两组(联合组和对照组),每组68例。对照组采用口服孟鲁司特钠治疗,联合组在对照组口服孟鲁司特钠基础上联合针刺肺经和大肠经腧穴治疗。比较两组临床疗效和临床症状改善时间。观察两组治疗前后气道阻力指标和血清α1-AG水平的变化。结果联合组总有效率高于对照组(P<0.05)。联合组胸闷、喘息、咳嗽、呼吸困难和气短的症状改善时间短于对照组(P<0.05)。两组治疗后气道阻力指标和血清α1-AG水平均较治疗前降低(P<0.05),且联合组治疗后气道阻力指标和血清α1-AG水平均低于对照组(P<0.05)。结论在口服孟鲁司特钠治疗基础上,针刺肺经及大肠经腧穴治疗支气管哮喘可提高临床疗效,缩短症状改善时间,降低气道阻力,调节血清α1-AG水平,优于单一口服孟鲁司特钠治疗。

Objective To observe the clinical efficacy of acupuncture at Lung Meridian and Large Intestine Meridian points plus Montelukast sodium in treating bronchial asthma(BA)and its effects on airway resistance and the serumα1-acid glycoprotein(α1-AG)level.Method A total of 136 BA patients were divided into two groups(a joint intervention group and a control group)using the random number table method,with 68 cases in each group.The control group was treated with oral Montelukast sodium,and the joint intervention group received acupuncture at Lung Meridian and Large Intestine Meridian points in addition to the same oral medication.The clinical efficacy and time spent improving clinical symptoms were compared.Post-treatment changes in the airway resistance indicators and serumα1-AG level were observed.Result The joint intervention group achieved a higher total effective rate compared with the control group(P<0.05).Compared with the control group,the joint intervention group took a shorter time to improve chest tightness,panting,coughing,difficulty breathing,and shortness of breath(P<0.05).After the treatment,the levels of airway resistance indicators and serumα1-AG dropped in both groups(P<0.05)and were lower in the joint intervention group than in the control group(P<0.05).Conclusion Based on oral administration of Montelukast sodium,acupuncture at Lung Meridian and Large Intestine Meridian points can enhance clinical efficacy,shorten the time in improving symptoms,reduce airway resistance,and regulate the serumα1-AG level in treating BA,surpassing the sole use of oral Montelukast sodium.