外泌体在口腔颌面组织再生中的研究进展

Study on exosomes in tissue regeneration in the oral and maxillofacial region

外泌体是细胞内拣选分离出的一种包裹蛋白、RNA等物质的膜性囊泡,通过循环系统远程调控其它细胞组织的生物学反应,在口腔颌面组织再生治疗中具有良好的应用前景。本文回顾了外泌体在牙髓、牙周、骨、皮肤、神经等口腔颌面组织再生工程领域的新进展,并结合笔者团队近几年在外泌体促进颌面组织再生机制方面的研究,总结口腔颌面组织再生、功能重建方面的经验,旨在为本领域研究提供参考借鉴,并展望以外泌体为基础的口腔颌面组织再生技术的临床转化应用前景。

Exosomes are a kind of membrane vesicles that encapsulate proteins,RNAs and other substances selected and isolated in cells,which can regulate the biological reactions of distal cells and tissues through the circulatory system,and have a good application prospect in the regeneration of oral and maxillofacial tissues.This article reviews the new progress of exosomes in the field of oral and maxillofacial tissue regeneration engineering such as dental pulp,periodontium,bone,skin,and nerve,and summarizes the experience of oral and maxillofacial tissue regeneration and functional reconstruction based on the research of exosomes in recent years.The purpose of this article is to provide reference for research in this field and to look forward to the clinical translation and application prospect of exosome-based oral and maxillofacial tissue regeneration technology.