全国细菌耐药监测网2014—2021年血标本分离毗邻颗粒链菌的耐药性变迁

Change in antimicrobial resistance of Granulicatella adiacens isolated from blood specimens,CARSS,2014-2021

目的了解全国临床血标本分离毗邻颗粒链菌的耐药性变迁,为临床治疗提供依据。方法按照全国细菌耐药监测网(CARSS)技术方案的要求开展细菌耐药监测工作,参考美国临床实验室标准化协会(CLSI)标准,分析2014—2021年CARSS成员单位血标本分离毗邻颗粒链菌对抗菌药物的敏感性数据。结果2014—2021年CARSS成员单位每年血标本临床分离毗邻颗粒链菌为83~152株,2017年后呈逐渐增多趋势。血标本分离毗邻颗粒链菌对万古霉素敏感率为100%,对美罗培南的敏感率为93.7%,对头孢曲松、头孢噻肟、头孢吡肟的敏感率为90%左右,对左氧氟沙星的敏感率为82.8%,对青霉素的敏感率为65.0%,对红霉素和克林霉素的敏感率较低,分别为32.7%、46.8%。2014—2021年毗邻颗粒链菌对部分抗菌药物的敏感率有不同程度上升,对头孢吡肟、美罗培南的敏感率有所下降。结论临床血标本毗邻颗粒链菌检出数量呈上升趋势,且对青霉素、头孢菌素、碳青霉烯类、氟喹诺酮类、大环内酯类均呈现不同程度耐药,但尚未发现对万古霉素耐药的菌株。

Objective To understand the change in antimicrobial resistance of Granulicatella adiacens(G.adiacens)clinically isolated from blood specimens in China,provide basis for clinical treatment.Methods Surveillance on antimicrobial resistance of bacteria was carried out according to the requirements of China Antimicrobial Resis-tance Surveillance System(CARSS).Antimicrobial susceptibility testing results of G.adiacens isolated from blood specimens of member units of CARSS in 2014-2021 were analyzed based on standard of American Clinical and Laboratory Standards Institute(CLSI).Results 83-152 strains of G.adiacens were isolated from blood specimens from member units of CARSS each year from 2014 to 2021,there was a gradual increasing trend after 2017.The susceptibility rates of G.adiacens isolated from blood specimens to vancomycin and meropenem were 100%and 93.7%respectively,to ceftriaxone,cefotaxime and cefepime were about 90%,to levofloxacin,penicillin,erythromycin and clindamycin were 82.8%,65.0%,32.7%and 46.8%,respectively.From 2014 to 2021,susceptibility rates of G.adiacens to partial antimicrobial agents increased to varying degrees,but to cefepime and meropenem decreased.Conclusion The number of G.adiacens isolated from blood specimens showed a rising trend,G.adiacens exhibits varying degrees of resistance to penicillin,cephalosporins,carbapenems,fluoroquinolones and macrolides,but no vancomycin-resistant strain was found.