非O1/O139群霍乱弧菌致肝硬化失代偿期患者血流感染1例

Bloodstream infection caused by non-O1/O139 Vibrio cholerae in patient with decompensated cirrhosis:one case report

患者,男性,58岁,乙型肝炎后肝硬化失代偿期、2型糖尿病12年,近1个月再发腹胀、水肿,尿少入院。住院期间患者寒战、发热,取血标本进行培养,选用头孢哌酮/舒巴坦经验性抗感染治疗。确诊非O1/O139霍乱弧菌引起的血流感染,药敏试验提示头孢哌酮/舒巴坦敏感后,继续使用当前药物,头孢哌酮/舒巴坦由3 g q12h改为3 g q8h治疗。10 d后患者无发热,血培养和粪便霍乱弧菌培养阴性,好转出院。

A 58-year-old male patient with decompensated cirrhosis after hepatitis B and typeⅡdiabetes for 12 years was admitted to hospital due to abdominal distension,edema and oliguria in recent one month.During hospitalization period,the patient experienced chills and fever,blood specimens were taken for culture,empirical anti-infection treatment with cefoperazone/sulbactam was given.The diagnosis of bloodstream infection caused by non-O1/O139 Vibrio cholerae was confirmed,antimicrobial susceptibility testing indicated that cefoperazone/sulbactam was sensitive,current antimicrobial agent was continued,cefoperazone/sulbactam 3 g q12h was changed to 3 g q8h treatment.After 10 days,the patient had no fever,blood and fecal cultures were negative for Vibrio cholerae,condition was improved and patient was discharged from the hospital.