蛋白质巯基亚硝基化修饰在心血管疾病中作用的研究进展

Research progress in roles of S-nitrosylation modification in myocardial diseases

心血管疾病是全球重大公共卫生问题,其发病机制及作用靶点的研究对临床诊治有重要意义。蛋白质翻译后修饰(post-translational modification,PTM)是一种调节蛋白功能的重要途径,主要包括酰化、磷酸化、甲基化、泛素化等。PTM参与了多种心血管疾病的发病过程,如心肌肥厚、心力衰竭、动脉粥样硬化、血管内皮损伤等。最近有不少研究发现蛋白质巯基亚硝基化(S-nitrosylation,SNO)修饰在心血管疾病中发挥重要的调控作用。本文简要综述了SNO修饰的形成与转化及对蛋白的调控在心肌肥厚、心力衰竭、动脉粥样硬化等常见心血管疾病中作用的研究进展。

Cardiovascular diseases are major global public health problems and research on the pathogenesis and targets of this disease is of great significance for clinical treatment.Post-translational modification(PTM)is an important pathway for regulating protein functions,including acylation,phosphorylation,methylation and ubiquitination.PTM is involved in the pathological process of various cardiovascular diseases,such as myocardial hypertrophy,heart failure,atherosclerosis and endothelial dysfunction.Recently,many studies have begun to focus on a protein post-translational modification,protein thiol nitrosylation(S-nitrosylation,SNO),which plays an important role in cardiovascular disease.This review briefly discusses the research progress of the formation and transformation of SNO modification as well as its roles in cardiac hypertrophy,heart failure,atherosclerosis,endothelial dysfunction and other common heart diseases.