经皮去肾神经术在非高血压疾病治疗中的进展

Percutaneous Renal Denervation in Treatment of Non-Hypertensive Diseases

近年来,经皮去肾神经术(RDN)作为一种微创介入治疗,通过破坏位于肾动脉附近的交感神经来中断肾交感神经活动,阻断肾和中枢交感神经系统之间的双向信号传递,可显著且安全地降低高血压患者的血压。而肾交感神经不仅在高血压中起重要作用,同时也在心血管疾病如心律失常和心力衰竭,非心血管疾病如阻塞性睡眠呼吸暂停、代谢性疾病和慢性肾脏病等非高血压疾病中起着至关重要的作用,RDN有望成为多种疾病的上游治疗措施。现就RDN治疗非高血压疾病做一综述。

In recent years,renal denervation(RDN),as a minimally invasive intervention treatment,interrupts renal sympathetic nerve activity by disrupting the sympathetic nerve located near the renal artery,blocking bidirectional signal transmission between the kidney and central sympathetic nervous system,and significantly and safely reducing blood pressure in hypertensive patients.The renal sympathetic nerve not only plays an important role in hypertension,but also plays a crucial role in cardiovascular diseases such as arrhythmia and heart failure,non cardiovascular diseases such as obstructive sleep apnea,metabolic disease and chronic kidney disease.RDN is expected to become an upstream treatment for various diseases.This article provides a review of RDN for the treatment of non-hypertensive diseases.