PCI后损伤血管再内皮化的机制与治疗研究进展

Mechanism and Therapy of Reendothelialization of Injured Vessels After Percutaneous Coronary Intervention

晚期支架内血栓形成是经皮冠状动脉介入治疗(PCI)后主要的并发症,严重影响了冠状动脉粥样硬化性心脏病患者的预后,带来不可逆转的危害。PCI后损伤血管再内皮化可减少晚期支架内血栓的形成,再内皮化的机制主要包括内皮细胞黏附和增殖的调控、平滑肌细胞黏附和增殖的调控、血小板黏附聚集和活化以及纤维蛋白原的吸附。对冠状动脉粥样硬化性心脏病患者血管损伤再内皮化机制的研究,可为损伤后血管重塑提供新的思路和治疗靶点,有利于提升PCI患者的预后。现就PCI后损伤血管再内皮化的相关机制和治疗进行综述。

Late stent thrombosis is a major complication of percutaneous coronary intervention(PCI)therapy,which seriously affects the prognosis of patients with atherosclerotic cardiovascular disease and causes irreversible harm.Reendothelialization of damaged vessels after PCI therapy is available to reduce late stent thrombosis.The mechanisms of reendothelialization mainly include the adhesion and proliferation of endothelial cell,the adhesion and proliferation of smooth muscle cell,the adhesive aggregation and activation of platelet,and the absorption of fibrinogen.The study on the mechanism of reendothelialization of vascular injury in patients with atherosclerotic cardiovascular disease provides new views and therapeutic targets for vascular remodeling after injury,which is conducive to improving the prognosis of patients undergoing PCI.This article reviews the relevant mechanism and therapy of reendothelialization of injured vessels after PCI.