摘要
沉默信息调节因子1(SIRT1)通过介导多种信号通路参与调节氧化应激、线粒体功能、细胞凋亡、炎症反应、内质网应激、纤维化等病理生理过程,在阿霉素诱导的心脏毒性中发挥保护作用。现总结SIRT1介导的信号通路在阿霉素诱导心脏毒性中的作用机制。
Silence information regulator 1(SIRT1)plays a protective role in doxorubicin-induced cardiotoxicity by mediating a variety of signaling pathways to participate in the regulation of oxidative stress,mitochondrial function,apoptosis,inflammatory response,endoplasmic reticulum stress,fibrosis and other pathological and physiological processes.This review summarizes the mechanisms of SIRT1-mediated signaling pathways in doxorubicin-induced cardiotoxicity.
作者
李登科
张伟
黄从新
LI Dengke;ZHANG Wei;HUANG Congxin(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute,Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2024年第3期257-260,共4页
Advances in Cardiovascular Diseases
基金
湖北省技术创新专项(2016ACA153)。
关键词
沉默信息调节因子1
信号通路
阿霉素
心脏毒性
Silence information regulator 1
Signal pathway
Doxorubicin
Cardiotoxicity
