脑梗死患者脑脊液溶血磷脂酸水平与神经功能缺损状态的相关性分析

Correlation between Cerebrospinal Fluid Lysophosphatidic Acid Level and Neurological Deficit in Patients with Cerebral Infarction

目的探讨与分析脑梗死(cerebral infarction,CI)患者脑脊液溶血磷脂酸(plasma lysophosphatidic acid,LPA)水平与神经功能缺损状态的相关性分析。方法选择2020年3月—2022年11月在北京市昌平区中西医结合医院诊治的67例脑梗死患者作为研究对象,所有患者在入院时进行神经功能缺损状态美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分,检测脑脊液溶血磷脂酸水平并进行相关性分析。结果在67例患者中,平均神经功能缺损状态NIHSS评分为(18.32±2.15)分,其中>21分17例(重度组)。重度组性别、身体质量指数、受教育程度、合并疾病等与非重度组对比,差异无统计学意义(P>0.05),重度组与非重度组的年龄、发病到入院时间等对比,差异有统计学意义(P<0.05)。重度组与非重度组的血糖、同型半胱氨酸、总胆固醇、甘油三酯含量对比,差异无统计学意义(P>0.05),重度组的低密度脂蛋白胆固醇含量高于非重度组,差异有统计学意义(P<0.05)。重度组的脑脊液溶血磷脂酸水平显著高于非重度组,差异有统计学意义(P<0.05)。Pearson分析显示NIHSS评分与年龄、发病到入院时间、脑脊液溶血磷脂酸水平都存在正相关性(P<0.05)。logistic回归分析显示年龄、发病到入院时间、脑脊液溶血磷脂酸水平为影响脑梗死患者NIHSS评分的重要因素(P<0.05)。结论脑梗死患者的神经功能缺损状态比较严重,神经功能缺损状态越差的脑梗死患者,脑脊液溶血磷脂酸水平越高,脑梗死患者脑脊液溶血磷脂酸水平与神经功能缺损状态存在相关性。

Objective To explore and analysis the correlation between cerebrospinalfluid lysophosphatidic acid(LPA)level and neurological deficit in patients with cerebral infarction(CI).Methods From March 2020 to November 2022,67 patients with cerebral infarction treated in Changping District Hospital of Integrated Traditional Chinese and Western Medicine in Beijing were selected as the study objects.All patients were scored with the National Institute of Health stroke scale(NIHSS)at admission,and the level of lysophosphatidic acid in cerebrospinal fluid was detected and analyzed.Results In the 67 patients,the average NIHSS score for neurological deficits were(18.32±2.15)points,with 17 cases(severe group)scoring above 21 points.There were no significant difference in gender,body mass index,education level,and comorbidities compared between the severe group and the non severe group(P>0.05).There were significant difference in age,onset to hospital admission time between the two groups(P<0.05).There were no significant difference in blood glucose,homocysteine,total cholesterol,and triglyceride levels between the two groups(P>0.05),while the low-density lipoprotein cholesterol levels in the severe group were higher than those in the non severe group(P<0.05).The level of lysophosphatidic acid in cerebrospinalfluid of severe group were significantly higher than that of non severe group(P<0.05).Pearson analysis showed that NIHSS score were positively correlated with age,time from onset to admission,and cerebrospinalfluid lysophosphatidic acid level(P<0.05).Logistic regression analysis showed that age,the time from onset to admission,and the level of lysophosphatidic acid in cerebrospinalfluid were the important factors influencing NIHSS scores in patients with cerebral infarction(P<0.05).Conclusion The neurological deficit status of patients with cerebral infarction is relatively serious.The worse the neurological deficit status of patients with cerebral infarction,the higher the level of lysophosphatidic acid in cerebrospinalfluid.The level of lysophosphatidic acid in cerebrospinalfluid of patients with cerebral infarction is related to the neurological deficit status.