金黄色葡萄球菌耐药机制及治疗药物

Mechanism of Drug Resistance and Treatment of Staphylococcus aureus

金黄色葡萄球菌(Staphylococcus aureus)是引起局部化脓和心内膜炎等多种感染的重要人兽共患革兰阳性病原菌。其传播速度快,致病力强,且耐药性日益严重,给全球公共卫生安全和动物养殖业造成了巨大威胁。这对深入了解金黄色葡萄球菌耐药机制以及药物新靶点的开发提出了迫切需求。因此,本文对当前临床使用的抗生素的作用机制和耐药机理进行了综述,并特别关注了相关领域的最新研究进展,以期望为临床防治细菌耐药和新药研制提供新的视角和参考。

Staphylococcus aureus(S.aureus)is a widespread Gram-positive zoonotic bacterial pathogen causing a variety of infections including septicemia and endocarditis.Due to its rapid spread,high pathogenicity and increasing drug resistance,S.aureus has become a serious threat to global public health and animal breeding.This has created an urgent need for an improved understanding of S.aureus mechanism-of-resistance and the discovery of drugs for potential targets.Therefore,this review summarized the mechanism-of-action and mechanism-of-resistance of anti-S.aureus in current clinical use,to provide new perspectives and references for the prevention and treatment of bacterial resistance and new drug development.