pH酸敏感性马来酸酰胺键的研究进展

Research Progress in pH Acid-Sensitive Maleic Acid Amide Bonds

与传统治疗方式相比,纳米药物给药系统具有较好的生物相容性、靶向性、控制或持续药物释放等优点,很大程度上提高了患者的依从性;显著增强渗透滞留(EPR)效应并降低药物的毒副作用。由于人体微环境存在pH差异,pH敏感性化学键作为刺激响应因子,在纳米药物给药系统中得到广泛研究,其中马来酸酰胺衍生物因其有趣的特性和潜力而受到关注。详细介绍了pH敏感性马来酸酰胺键酸触变机理,及其化学键断裂和质子化作用控释机制,并围绕马来酸酰胺键化学结构优势及其在纳米载药体系中的应用研究展开分析论述。

Compared with traditional treatment methods,nano drug delivery system has better biocompatibility,targeting,control or continuous drug release and other advantages,which greatly improves patient compliance.Significantly enhance EPR effect and reduce the toxic side effects of drugs.Due to pH differences in the human microenvironment,pH-sensitive chemical bonds have been extensively studied as stimulus response factors in nanodrug delivery systems.Among them,ma⁃leic amide derivatives have attracted much attention due to their interesting properties and potential.In this paper,the thixotropic mechanism of ph-sensitive maleidoamide bond and the mechanism of chemical bond breaking and protonation control are introduced in detail.The advantages of the chemical structure of maleic acid amide bond and its application in nano drug delivery system were analyzed and discussed.