溶剂-抗溶剂体系及PEG对PCL静电喷雾颗粒形貌的影响

Effect of Solvent-Antisolvent System and PEG on Particle Morphology of PCL Electrostatic Spray

为了研究静电喷雾技术制备不同形貌微球的形成机理,采用聚己内酯(PCL)作为研究对象,使用二氯甲烷(DCM)、二氯甲烷-N,N-二甲基甲酰胺(DMF)作为溶剂,研究不同收集距离、电压、溶剂比例以及收集介质对静电喷雾技术制备PCL微球颗粒形貌的影响。此外,还研究了添加聚乙二醇(PEG)对产品形貌的影响。实验结果表明,使用DCM做为溶剂时,获得了高尔夫球形貌的颗粒;使用DCM/DMF为9∶1作为溶剂,收集介质为无水乙醇时,获得了碗状颗粒;在电喷溶液中添加PEG后,获得了聚合物串珠。

In order to study the formation mechanism of different morphologies of PCL microspheres prepared by electro⁃static spraying technology,we used polycaprolactone(PCL)as the research object and dichloromethane(DCM),di⁃chloromethane-N,N-dimethylformamide(DMF)as the solvent to study the effects of different collection distances,voltages,solvent ratios and collection media on the morphologies of PCL microspheres prepared by electrostatic spray technology.In addition,the effect of adding polyethylene glycol(PEG)on the morphology of the product was also stud⁃ied.The experimental results showed that when DCM was used as a solvent,golf ball shaped particles were obtained.When DCM/DMF was used as a solvent with a ratio of 9∶1 and the collection medium was ethanol,bowl shaped parti⁃cles were obtained.After adding PEG to the electrospray solution,polymer beads were obtained.