川西高原藏族家庭幽门螺杆菌感染的流行病学现况和相关因素分析

Epidemiology and associated factors of Helicobacter pylori infection in Tibetan families on the Western Sichuan Plateau

目的了解川西高原藏族家庭及其个体的幽门螺杆菌感染状况,并探讨影响幽门螺杆菌感染的相关因素。方法本研究为单中心横断面研究。于2023年3月至5月纳入川西高原地区50户藏族家庭,共计155名研究对象。采用问卷的方式调查纳入对象幽门螺杆菌感染相关资料,并以13C-尿素呼气试验检测其幽门螺杆菌感染情况。采用二元logistic回归分析幽门螺杆菌感染的相关因素。结果50户藏族家庭中,个体幽门螺杆菌感染率为47.10%(73/155);9名未成年人中有2例感染,成年人感染率为48.63%(71/146),18~40岁的感染率为55.00%(11/20)。家庭感染率为80.00%(40/50),其中16.00%(8/50)的家庭中所有成员均感染。50户家庭共有59对夫妇,其中14对(23.73%)同时感染,27对(45.76%)仅一方感染。6户家庭有未成年人,其中2户存在儿童感染。家庭人数与幽门螺杆菌感染相关[比值比(OR)=3.038,95%可信区间(CI)1.043~10.491,P=0.042]。结论川西高原藏族家庭的幽门螺杆菌感染率较高,家庭人数越多,家庭内感染幽门螺杆菌的风险越大。

Objective To investigate the Helicobacter pylori(H.pylori)infection of Tibetan families and individuals in the Western Sichuan Plateau region and explore the related factors which affected H.pylori infection.Methods This was a single-center cross-sectional study.Questionnaires were collected from 50 Tibetan families including 155 individuals in Western Sichuan Plateau region during March to May 2023.The 13C-urea breath test was performed to confirm the current infection status of participants.Binary logistic regression were used to analyze the related factors associated with H.pylori infection.Results Among the 50 Tibetan households,the individual-based H.pylori infection rate was 47.10%(73/155),with two out of nine children and 48.63%(71/146)adults infected.The age group of 18 to 40 years had the highest infection rate(55.00%,11/20).The prevalence of infection based on family was 80.00%(40/50),of which 16.00%(8/50)had all family members infected.Of the 59 couples surveyed,23.73%(14/59)were both infected,and 45.76%(27/59)had one person infected.Of the six families which had children and adolescents,two households had their children infected.Logistic regression analysis showed that size of the family was a factor related to H.pylori infection(odds ratio=3.038,95%confidence interval 1.043 to 10.491,P=0.042).Conclusions The family-based H.pylori infection rate is relatively high in Tibetan residents in the Western Sichuan Plateau,and larger family size is related with higher risk of H.pylori infection within the family.