丹红注射液联合阿替普酶对急性脑梗死患者神经功能凝血功能及血管内皮功能的影响

Effect of Danhong injection combined with alteplase on neurological function,coagulation function,and vascular endothelial function in patients with acute cerebral infarction

目的探讨丹红注射液联合阿替普酶对急性脑梗死(ACI)患者神经功能、凝血功能及血管内皮功能的影响。方法选取2022年1月至2023年1月驻马店市中医院收治的ACI患者98例,按照随机数字表法将其分为2组,各49例。对照组采用阿替普酶治疗,观察组联合丹红注射液治疗,2组均连续治疗2周。比较2组临床疗效、神经功能、凝血功能、血管内皮功能以及不良反应。结果相较于对照组,观察组治疗后总有效率更高(P<0.05);相较于对照组,观察组治疗后美国国立卫生卒中量表(NIHSS)评分更低(P<0.05);相较于对照组,观察组治疗后部分凝血活酶时间(APTT)、凝血酶原时间(PT)、血浆凝血酶时间(TT)水平更高,纤维蛋白原(FIB)水平低(P<0.05);相较于对照组,观察组治疗后血管内皮素(ET-1)水平更低,血清一氧化氮(NO)、血管内皮生长因子(VEGF)水平更高(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论ACI患者采用丹红注射液联合阿替普酶治疗可有效修复受损神经,促进患者神经功能恢复,改善患者凝血功能,调节血管内皮细胞作用机制,增强其血管内皮功能,且临床应用无明显不良反应,安全性较高。

Objective To investigate the effects of Danhong injection combined with ateplase on neurological function,coagulation function,and vascular endothelial function in patients with acute cerebral infarction(ACI).Methods Ninety-eight ACI patients admitted to Zhumadian Traditional Chinese Medicine Hospital from January 2022 to January 2023 were selected and divided into two groups using a random number table method,with 49 patients in each group.The control group was treated with ateplase,while the observation group was treated with Danhong injection.Both groups were treated continuously for 2 weeks.The clinical efficacy,neurological function,coagulation function,vascular endothelial function,and adverse reactions between the two groups were compared.Results Compared with the control group,the observation group had a higher overall effective rate after treatment(P<0.05),a lower score on the National Health Stroke Scale(NIHSS)after treatment,and higher levels of partial thromboplastin time(APTT),prothrombin time(PT),and plasma thromboplastin time(TT)after treatment,while lower levels of fibrinogen(FIB)(P<0.05).Compared with the control group,the observation group had lower levels of endothelin 1(ET-1)and higher levels of serum nitric oxide(NO),and vascular endothelial growth factor(VEGF)after treatment(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Treating ACI patients with Danhong injection combined with alteplase can effectively repair damaged nerves,promote the recovery of neurological function,improve coagulation function,regulate the mechanism of action of vascular endothelial cells,and enhance their vascular endothelial function.Moreover,there are no significant adverse reactions in clinical application,and the safety is high.