轻度认知障碍与肠道微生物群的相关性研究进展

Research progress on the correlation between mild cognitive impairment and gut microbiota

轻度认知障碍(MCI)是正常衰老至痴呆发展中的一种认知损伤症候群。近几年老年人认知损伤发病率越来越高,已成为当今社会老年人的严重问题。肠道微生物群(GM)在MCI的发展中起重要作用,可影响大脑的行动及认知能力,促进MCI的发生发展过程;此外,GM还与不同类型的MCI具有相关性。本文从认知功能下降与GM失调的相关性、不同类型MCI与GM失调的关系、GM影响MCI的相关机制、中医药干预GM改善认知障碍等方面综述GM在MCI发生发展中的作用,分析GM是否可成为MCI预防、治疗的新靶点,以期为临床防治MCI提供参考。

Mild cognitive impairment(MCI)is a cognitive impairment syndrome that occurs from normal aging to dementia.In recent years,the incidence of cognitive impairment in the elderly has become higher and higher,which has become a serious problem for the elderly in today′s society.Studies suggest that gut microbiota(GM)plays an important role in the development of MCI,which can affect the brain′s action and cognitive ability,and then promote the occurrence and development of MCI.In addition,gut microbiota is also associated with different types of MCI.Therefore,this paper reviews the influence of gut microbiota in the occurrence and development of MCI from four aspects:the correlation between cognitive decline and intestinal dysbacteriosis,the relationship between different types of mild cognitive impairment and intestinal dysbacteriosis,the relevant mechanism of gut microbiota affecting mild cognitive impairment,and the intervention of traditional Chinese medicine in improving cognitive impairment of gut microbiota,and analyzes whether gut microbiota can become a new target for the prevention and treatment of MCI,in order to bring inspiration for the clinical prevention and treatment of mild cognitive impairment.