长链非编码RNA烟酰胺核苷酸转氢酶-反义RNA1在肺癌发生发展中的作用研究进展

Research progress on the role of long non-coding RNA nicotinamide nucleotide transhydrogenase-antisense RNA1 in the occurrence and development of lung cancer

肺癌是世界上致死率最高的恶性肿瘤,其主要治疗手段为外科手术、化学治疗、放射治疗、靶向治疗等。烟酰胺核苷酸转氢酶-反义RNA1(NNT-AS1)作为新发现的长链非编码RNA(lncRNA)分子,通过miR-3666/E2F2、miR-22-3p/YAP1、miR-22/FOXM1、miR-1236-3p/ATG7、miR-129-5p、丝裂原活化蛋白激酶/Slug等信号通路,与肺癌细胞的凋亡、增殖、迁移、侵袭有关,还参与介导肺癌细胞的顺铂耐药性,与肺癌的不良生存结局和较差的临床病理特征显著相关,可以为肺癌提供新的治疗靶点及预后标志物。本文就lncRNA NNT-AS1在肺癌发生发展中的作用研究进展进行综述。

Lung cancer is the malignant tumor with the highest fatality rate in the world,and its main treatment methods are surgery,chemotherapy,radiotherapy,and targeted therapy.Recent studies have found that nicotinamide nucleotide transhydrogenase-antisense RNA1(NNT Antisense RNA 1,NNT-AS1),as a newly discovered long non-coding RNA(LncRNA)molecule,is correlated with the apoptosis,proliferation,migration and invasion of lung cancer tissues and cells through miR-3666/E2F2,miR-22-3p/YAP1,miR-22/FOXM1,miR-1236-3p/ATG7,miR-129-5p,Mitogen-activated protein kinase/Slug and other signaling pathways,and is also involved in the mediation of cisplatin resistance in lung cancer.NNT-AS1 is significantly associated with poor survival outcomes and poor clinicopathological characteristics of lung cancer,which can provide new therapeutic targets and prognostic markers for lung cancer.This article reviews the research progress on the role of LncRNA NNT-AS1 in the occurrence and development of lung cancer.