慢性肾脏病非透析患者心脏瓣膜钙化的影响因素及对预后的影响

Influencing Factors of Cardiac Valve Calcification in Non Dialysis Patients with Chronic Kidney Disease and Its Impact on Prognosis

目的:探讨慢性肾脏病(chronic kidney disease,CKD)非透析患者心脏瓣膜钙化(cardiac valve calcification,CVC)的影响因素及对预后的影响。方法:回顾性选取2019年3月—2021年3月福建医科大学附属泉州第一医院收治的CKD非透析患者312例为研究对象,收集患者的一般情况、实验室检查及心脏彩超等资料。随访截止时间为2022年6月。分析CKD非透析患者CVC的影响因素,以及CVC与预后的关系。结果:CVC组年龄、高血压史和糖尿病史比例均高于非CVC组(P<0.05);CVC组总胆固醇和肾小球滤过率水平均低于非CVC组(P<0.05);CVC左心室肥厚率高于非CVC组(P<0.05)。logistic回归结果显示,年龄、高血压史、糖尿病史、总胆固醇、肾小球滤过率、左心室肥厚均为CVC的影响因素(P<0.05);CVC组患者的全因死亡率34.31%较非CVC组的2.86%高(P<0.05)。结论:年龄、高血压史、糖尿病史、总胆固醇、肾小球滤过率、左心室肥厚均为CKD非透析患者CVC的影响因素,CVC可以增加该类患者的全因死亡率。

Objective:To investigate the influencing factors of cardiac valve calcification(CVC)in non dialysis patients with chronic kidney disease(CKD)and Its impact on prognosis.Method:A total of 312 non dialysis patients with CKD admitted to Quanzhou First Hospital Affiliated to Fujian Medical University hospital from March 2019 to March 2021 were retrospectively selected as the study subjects,and data on their general conditions,laboratory examinations,and cardiac color Doppler ultrasound were collected.The deadline for follow-up was June 2022.The influencing factors of CVC in non dialysis patients with CKD and the relationship between CKC and prognosis were analyzed.Result:The age,history of hypertension and history of diabetes in CVC group were higher than those in non CVC group(P<0.05).The total cholesterol and glomerular filtration levels of patients in the CVC group were lower than those in the non CVC group(P<0.05).The left ventricular hypertrophy rate in the CVC group was higher than that in the non CVC group(P<0.05).logistic regression results showed that age,history of hypertension,history of diabetes,total cholesterol,glomerular filtration rate,and left ventricular hypertrophy were all factors influencing CVC(P<0.05).The all-cause mortality rate of patients in the CVC group was 34.31%,higher than 2.86%in the non CVC group(P<0.05).Conclusion:Age,history of hypertension,history of diabetes,total cholesterol,glomerular rate filtration and left ventricular hypertrophy are the influencing factors of CVC in non dialysis CKD patients,and CVC can increase the all-cause mortality of these patients.