摘要
从中医药干预核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体入手,阐述中医药发挥抗炎的作用机理,认为NLRP3炎症小体参与的炎症反应贯穿动脉粥样硬化(atherosclerosis,AS)发展的全过程,其中清热药、活血药及补虚药在治疗AS中具有极大优势,为中医药治疗AS疾病提供新思路。
Based on the intervention of traditional Chinese medicine on nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,the paper discussed the anti-inflammatory mechanism of traditional Chinese medicine.It is believed that inflammatory response involved in NLRP3 runs through the entire process of the development of atherosclerosis(AS).Among them,heat-clearing drugs,blood-activating drugs and deficiency-tonifying drugs have great advantages in the treatment of AS,providing new ideas for traditional Chinese medicine treatment of AS.
作者
陈晋玉
雷瑗琳
王南丁
CHEN Jinyu;LEI Yuanlin;WANG Nanding(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Xi′an Hospital of Traditional Chinese Medicine,Xi′an 710021,China)
出处
《西部中医药》
2024年第4期112-116,共5页
Western Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81503444)
陕西省自然科学基础研究计划(2020JQ-966)
西安市科协青年人才托举计划(095920201330)。
关键词
动脉粥样硬化
核苷酸结合寡聚化结构域样受体蛋白3
炎症小体
中医药
atherosclerosis
nucleotide-binding oligomerized structural domain-like receptor protein 3
inflammasome
Chinese medicine
