丹黄化浊通瘀丸治疗痛风性肾病的临床研究

Clinical Study of Danhuang Huazhuo Tongyu Pills in the Treatment of Gouty Nephropathy

目的:观察丹黄化浊通瘀丸治疗痛风性肾病的疗效及安全性。方法:选取痛风性肾病患者100例,随机分为观察组和对照组,每组50例。对照组予以调节血脂、止痛等对症处理,并口服别嘌呤醇及坎地沙坦,观察组在此基础上口服丹黄化浊通瘀丸。两组均于治疗12周后评定疗效,并测定治疗前后血尿酸、24 h尿蛋白定量、尿微量白蛋白/肌酐、β_(2)微球蛋白及不良反应发生情况。结果:观察组总有效率[94.0%(47/50)]高于对照组[78.0%(39/50)](P<0.05)。两组血尿酸、24 h尿蛋白、尿微量白蛋白/肌酐、β_(2)微球蛋白均较治疗前下降(P<0.05);其中血尿酸、β_(2)微球蛋白观察组较对照组下降更明显(P<0.05)。两组用药前后血常规、肝肾功能未见明显变化,无明显不良反应发生。结论:在常规应用西药治疗的基础上,以丹黄化浊通瘀丸治疗痛风性肾病可明显降低尿酸、减少蛋白尿,改善临床症状,且安全可靠。

Objective:To observe the therapeutic efficacy and safety of Danhuang Huazhuo Tongyu pills(Danhuang Turbidity-resolving Stasis-removing pills)in the treatment of gouty nephropathy.Methods:All 100 cases of gouty nephropathy were selected and randomly divided into observation group and control group,50 cases in each group.The control group was treated with symptomatic treatments such as regulating blood lipids,pain relief,and oral allopurinol and candesartan,while the observation group was treated with Danhuang Huazhuo Tongyu pills on the basis of this treatment the control group accepted.Both groups were evaluated after 12 weeks of treatment,and blood uric acid,24 h urine protein quantification,urine microalbumin/creatinine,β_(2)micro-globulin and the occurrence of adverse reactions were measured before and after treatment.Results:The total effective rate of the observation group[94.0%(47/50)]was higher than that of the control group[78.0%(39/50)](P<0.05).Serum uric acid,24-hour urine protein,urinary microalbumin/creatinine,andβ_(2)microglobulin in both groups were all reduced compared with before treatment(P<0.05);among them,serum uric acid andβ_(2)microg-lobulin in the observation group were decreased more than those in the control group(P<0.05).There was no significant changes in blood routine,liver and kidney function before and after treatment in the two groups,and no obvious adverse reactions occurred.Conclusion:On the basis of conventional application of Western medicine,the treatment of gouty nephropathy with the pill can obviously reduce uric acid and proteinuria,improve clinical symptoms,which is safe and reliable.