重金属污染物诱导的糖尿病肾病

Diabetic nephropathy induced by heavy metal pollutants

全球范围内的重金属污染加剧,对人类造成的威胁程度不断上升。金属离子进入人体后在肝脏、心脏、肾脏和大脑等重要的身体器官中积聚,扰乱正常的生物功能。糖尿病肾病是一种常见的肾脏疾病。除遗传外,环境因素已经逐渐成为人们关注的促进糖尿病向糖尿病肾病发展的一个主要原因。近年来研究显示,重金属暴露会增加该疾病的风险。本文通过铁、镉、铅等重金属离子对糖尿病肾病的影响、氧化应激和金属硫蛋白在重金属离子诱导糖尿病肾病中的介导作用,以及金属硫蛋白的主要金属锌通过抗氧化延缓糖尿病肾病的作用进行综述,为糖尿病肾病的预防和治疗提供理论依据。

Heavy metal pollution has intensified worldwide and poses an increasing threat to humanity.Metal ions enter the body and accumulate in vital body organs such as the liver,heart,kidneys and brain,disrupting their normal biological functions.Diabetic nephropathy(DN)is a common kidney disease.In addition to genetics,the environmental factors have gradually become a major cause of promoting the development of DN.In recent years,the studies have shown that exposure to heavy metals increases the risk of DN.In this paper,the effects of ferrum,cadmium,lead and other heavy metal ions on diabetic nephropathy,oxidative stress and the mediating role of metallothionein in diabetic nephropathy induced by heavy metal ions,and the role of metallothionein′s main metal zinc in delaying diabetic nephropathy through anti-oxidation are reviewed,providing theoretical basis and reference for the prevention and treatment of diabetic nephropathy in the future.