超声引导下靶点注射甲钴胺对周围神经损伤康复效果分析

Application of ultrasound-guided target injection of mecobalamin in rehabilitation treatment of peripheral nerve injury

目的观察超声引导下靶点注射甲钴胺对周围神经损伤康复效果。方法选取120例周围神经损伤患者,按照随机数字表法分为常规组和试验组,每组60例。常规组实施常规康复治疗,试验组采用超声引导下靶点注射甲钴胺治疗,比较两组治疗前后神经功能血清指标、电生理活动改善情况,神经结构、感觉功能变化情况。结果治疗后,试验组的BDNF、NGF、NT-3、SCV、MCV均高于常规组,差异有统计学意义(P<0.05);两组神经直径及横截面积均有下降,但试验组的神经直径、神经横截面积均高于常规组(P<0.05);治疗4周后、8周后、12周后,试验组的BMRC评分均高于常规组(P<0.05)。结论超声引导下靶点注射甲钴胺能有效改善周围神经损伤患者神经功能血清指标,对促进患者神经电生理活动、神经结构及神经感觉功能恢复均有积极意义。

Objective To observe the effect of ultrasound guided target injection of mecobalamin on the rehabilitation of peripheral nerve injury.Methods 120 patients with peripheral nerve injury were divided into the conventional group and experimental group using a number table method,with 60 cases in each group.The conventional group were treated with routine rehabilitation,while the experimental group were received multi target injection of mecobalamin under ultrasound guidance in combination with treatment.The improvement of neurological function serum indicators,electrophysiological activities,and changes in neurological structure and sensory function were compared between the two groups of patients before and after treatment.Results After treatment,brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),neurotrophin-3(NT-3),sensory nerve conduction velocity(SCV),and motor nerve conduction velocity(MCV)of the experimental group were higher than those of the conventional group,and the difference between two groups was statistically significant(P<0.05);the nerve diameter and cross-sectional area of both groups decreased,but the nerve diameter and cross-sectional area of the experimental group were higher than those of the conventional group(P<0.05);BMRC scores of the experimental group after 4 weeks of treatment,8 weeks of treatment,and 12 weeks of treatment were higher than those of the conventional group(P<0.05).Conclusion Ultrasound guided target injection of mecobalamin can effectively improve the serum indicators of neurological function in patients with peripheral nerve injury,and has a positive significance in promoting the recovery of patients′neuro electrophysiological activity,neural structure,and sensory function.