CTRP6与妊娠期糖尿病患者糖脂代谢功能的相关性

Correlation between CTRP6 and glucose and lipid metabolism in pregnant women with diabetes

目的分析C1q/肿瘤坏死因子相关蛋白6(CTRP6)与妊娠期糖尿病(GDM)患者糖脂代谢功能的相关性。方法选取50例GDM患者列为病例组,另选择同期孕检的66例正常产妇列为对照组,比较两组的一般资料(年龄、孕周、体质量指数、产次),临床资料(血糖指标、血脂指标、胰岛素功能、CTRP6表达),采用单因素分析、Logistic多因素回归分析归纳可导致GDM发病的危险因素,经Spearman相关性系数验证CTRP6表达与GDM患者糖脂代谢指标及胰岛素功能的相关性。结果Logistic多因素回归分析结果显示,空腹血糖(FBG)≥10.0 mmol/L、糖化血红蛋白(HbA1c)≥10%、甘油三酯(TG)≥2.5 mmol/L、低密度脂蛋白胆固醇(LDL-C)≥2.0 mmol/L、载脂蛋白A5(ApoA5)≤100μg/L、CTRP6≥600μg/L、空腹胰岛素(FINS)≥10 mU/L、胰岛β细胞功能(HOMA-β)≤50、胰岛素抵抗(HOMA-IR)≥2.25为发生GMD的危险因素。经Spearman相关性系数检验,CTRP6表达水平与FBG、HbA1c、TG、LDL-C、FINS、HOMA-IR正相关,与ApoA5、HOMA-β负相关。结论CTRP6表达水平随FBG、HbA1c、TG、LDL-C、FINS、HOMA-IR升高,随ApoA5、HOMA-β降低而不断上升。

Objective To analyze the relationship between C1q/tumor necrosis factor related protein 6(CTRP6)and glucose and lipid metabolism in patients with gestational diabetes(GDM)and the potential mechanism in the pathogenesis of GMD.Methods 50 GDM patients were selected as the case group,and 66 normal postpartum women who underwent pregnancy examination during the same period were selected as the control group.The general data(age,gestational age,body mass index,parity)and clinical data(blood glucose indicators,blood lipid indicators,insulin function,CTRP6 expression)of the two groups of postpartum women were compared,and the risk factors that can lead to GDM were summarized using univariate analysis and logistic multiple regression analysis.Verified by Spearman correlation coefficient,the correlation between CTRP6 expression and glucose and lipid metabolism indicators in GDM patients was analyzed.Results Logistic multivariate regression analysis showed that fasting blood glucose(FBG)≥10.0 mmol/L,glycated hemoglobin(HbA1c)≥10%,triglycerides(TG)≥2.5 mmol/L,low-density lipoprotein cholesterol(LDL-C)≥2.0 mmol/L,and apolipoprotein A5(ApoA5)≤100μg/L,CTRP6≥600μg/L fasting insulin(FINS)≥10 mU/L,isletβCell function(HOMA-β)≤50.Homeostasis model assessment for insulin resistance(HOMA-IR)≥2.25 is a risk factor for the occurrence of GMD.According to Spearman correlation coefficient test,the expression level of CTRP6 is positively correlated with FBG,HbA1c,TG,LDL-C,FINS,HOMA-IR,and with ApoA5 and HOMA-βNegative correlation.Conclusion CTRP6 will continuously increase with the increase of FBG,HbA1c,TG,LDL-C,FINS,HOMA-IR,and the decrease of ApoA5,HOMA-β.