2018-2021年某院血流感染病原菌构成及耐药性分析

Pathogen composition and drug resistance analysis of bloodstream infection in a hospitalfrom 2018 to 2021

目的分析2018-2021年西藏地区某医院住院患者血流感染病原菌构成特点及耐药性,为本地区血流感染的经验性治疗提供科学依据。方法回顾性分析某院4年期间住院患者血培养阳性的标本,汇总病原菌的构成特点及药敏结果,采用WHONET 5.6软件、SPSS软件进行数据统计及分析。结果4年间从临床送检验的血培养标本中共培养分离获得751株病原菌(剔除了同一病人相同标本类型的重复检出病原体)。其中396株(52.7%)为革兰阳性菌,343(45.7%)为革兰阴性菌,12株(1.6%)为真菌。结论该院2018-2021年间血流感染以革兰阳性菌为主。主要病原菌对常用抗菌药物的耐药性也呈上升趋势,应加强对血流感染常见菌群的分布及耐药性的监测,更合理使用针对性的抗菌药物。

Objective To analyze the composition and drug resistance of pathogens causing bloodstream infection in the hospital in Tibet from 2018 to 2021,and to provide scientific basis for the empirical treatment of bloodstream infection in the region.Meth-ods The positive blood culture samples of hospitalized patients in a hospital during 4 years were retrospectively analyzed,and the composition characteristics of pathogenic bacteria and drug sensitivity results were summarized.The data were statistically analyzed by WHONET 5.6 software and SPSS software.Results A total of 751 strains of pathogenic bacteria were isolated from the blood cul-ture specimens of the patients during the 4 years(excluding the repeated detection of pathogens from the same specimen type of the same patient).Among them,396(52.7%)were Gram-positive bacteria,343(45.7%)were Gram-negative bacteria,and 12(1.6%)were fungi.Conclusions The bloodstream infections in this hospital from 2018 to 2021 are mainly Gram-positive bacteria.The resis-tance of main pathogens to commonly used antibiotics is also on the rise.It is necessary to strengthen the monitoring of the distribu-tion and drug resistance of common bacteria in bloodstream infection,and use targeted antibiotics more rationally.