化学性瘙痒中枢神经传导回路的研究进展

Progress in the Central Nervous System Transmission Circuit of Chemical Pruritus

瘙痒是一种复合感觉,包含感觉、情绪和动机成分,其传导与处理涉及到脊髓和大脑多个回路。主要包括感觉由脊髓上行至各个脑区,各个脑区参与瘙痒感觉的不同层面处理,下行瘙痒信号调节以及瘙痒的情绪和动机反应。深入认识瘙痒神经传导回路,有助于推动瘙痒机制的研究并指导临床治疗策略的开发。

Itch is a complex sensation that includes sensory,emotional,and motivational components.Its con-duction and processing involve multiple circuits in the spinal cord and brain.This primarily includes the sensation being projected from the spinal cord to various brain regions with each region participating in the processing of dif-ferent aspects of the itch sensation,the regulation of descending itch signals and the emotional and motivational re-sponses to itch.Gaining a deeper understanding of the neural circuitry of itch can be conducive to the future re-search on the mechanisms of itch and guide the development of clinical treatment strategies.