粒细胞集落刺激因子在生殖领域中的应用研究进展

Research progress on the application of granulocyte colony-stimulating factor in the field of reproduction

国内外研究显示,粒细胞集落刺激因子(G-CSF)可通过改善子宫内膜容受性,促进母-胎界面血管重铸,调节母-胎界面免疫耐受,减少不良妊娠结局,故逐渐广泛用于生殖领域。但目前对于G-CSF的用法、用量无统一共识,本文总结其在生殖领域的复发性流产和反复种植失败中的应用,以期更好地指导临床使用。

Domestic and foreign studies have shown that granulocyte colony-stimulating factor(G-CSF) can improve endometrial receptivity,promote maternal fetal interface vascular recasting,regulate maternal fetal interface immune tolerance and reduce adverse pregnancy outcomes.Therefore,it is gradually widely used in the reproductive field.However,there is currently no unified consensus on the usage and dosage of G-CSF.This article summarizes the application of G-CSF in recurrent miscarriage and recurrent implantation failure in the reproductive field,in order to better guide clinical use.