疑似阿昔洛韦致儿童药物性肝损伤报道1例

A case report of suspected drug-induced liver injury caused by Acyclovir in children

药物性肝损伤是最常见的不良反应之一。本文报道1例疑似使用阿昔洛韦后导致药物性肝损伤患儿,患儿使用阿昔洛韦后出现转氨酶异常升高,临床药师结合相关指南及文献,对病情进行分析和干预,经过治疗后转氨酶水平逐渐恢复正常。当患儿出现药物性肝损伤时,临床药师应利用自身的专业知识并结合患儿病情查找药物性肝损伤的原因,优化治疗方案,协助临床医师完成治疗,保障患儿的用药安全。

Drug-induced liver injury is one of the most common adverse reactions.This paper reports a case of suspected drug-induced liver injury caused by Acyclovir.The abnormal elevation of transaminase occurred after Acyclovir treatment in children.Clinical pharmacists analyzed and intervened the condition based on relevant guidelines and literature,and the transaminase levels gradually returned to normal after treatment.When children have drug-induced liver injury,clinical pharmacists should use their professional knowledge and combine with the condition of children to find the cause of drug-induced liver injury,optimize the treatment plan,assist clinicians to complete the treatment,and ensure the safety of children's medication.