胆固醇代谢在骨关节炎疾病中的作用及研究进展

Role of cholesterol metabolism in osteoarthritis:a review of research progresses

骨关节炎(osteoarthritis,OA)是一种与年龄相关的退行性疾病,长期以来一直与肥胖有关。有研究指出OA可能是一种代谢性疾病,因为它不仅累及负重关节也累及非负重关节。新出现的证据表明OA中存在着异常的胆固醇代谢。异常的胆固醇代谢途径会伴随着产生一些促炎物质,这些物质对OA的发展至关重要。因此调节胆固醇异常代谢的药物可能在OA中具有巨大的治疗前景。现着重总结了胆固醇代谢在OA疾病中的作用和综合分子机制,提出多角度调控胆固醇代谢可能是临床治疗OA疾病的一种有前景的策略。

Osteoarthritis(OA)is a degenerative disease associated with aging and has long been linked to obesity.Some studies suggest that OA might be a metabolic disease,impacting not only weight-bearing joints but also non-weight-bearing joints.Emerging evidence indicates abnormal cholesterol metabolism in osteoarthritis,with pathways leading to the production of pro-inflammatory substances crucial to OA development.Drugs capable of modulating abnormal cholesterol metabolism hold considerable therapeutic promise for OA.This article aims to summarize the role and comprehensive molecular mechanisms of cholesterol metabolism in osteoarthritis and proposes that a multi-faceted regulation of cholesterol metabolism could be a promising strategy for the clinical treatment of osteoarthritis.