基于CiteSpace的国内外亚硫酸盐及其添加剂安全性研究文献计量分析

Bibliometric Analysis of Domestic and Foreign Literature on Safety of Sulfite and Its Additives Based on CiteSpace

目的分析并总结近40年来国内外关于亚硫酸盐及其添加剂安全性研究的热点、规律和分布情况,为促进我国未来亚硫酸盐及其添加剂的安全性研究与监督管理提供参考。方法在Web of Science核心合集数据库和中国国家知识基础设施(CNKI)数据库中,以“亚硫酸盐”“添加剂”“安全性”等主题词组成检索式进行文献检索,借助CiteSpace软件对筛选后文献的合作网络以及关键词网络进行可视化处理与分析,总结国内外研究现状。结果国内外的研究热点普遍集中在对亚硫酸盐及其添加剂的不良事件报道与安全性综述、安全性研究、新型检测方法的研究与实际应用4个方面。此外,国外还开展了亚硫酸盐与其他药物联用的不良反应组合探索、相关产品的上市后安全性评价等研究;我国则对于亚硫酸盐的新应用、中药材中亚硫酸盐的检测以及亚硫酸盐限量标准设定展开了更多的研究。结论我国现有研究力度有待加强且深度不足,导致安全性基础研究与监督管理脱节。加强国内外更多主体的合作、拓宽研究范围主动引入风险管理研究、加强相关产品上市后安全性监督管理,是促进亚硫酸盐及其添加剂安全性保障的有效途径。

Objective To analyze and summarize the hot spots,patterns,and distribution of the safety studies on sulfites and their additives in China and abroad in the past 40 years,and to provide a reference for promoting the safety research and supervision of sulfites and their additives in China in the future.Methods In the Web of Science Core Collection database and China National Knowledge Infrastructure(CNKI)database,the relevant literature was searched by"sulfite","additives","safety"and other subject terms.Relevant literature was searched,and the cooperation network and keyword network of the screened literature were visualized and analyzed with the help of CiteSpace software,to summarize the current status of the research at home and abroad.Results The hotspots of China and foreign research generally focus on the four aspects of adverse event reports and safety reviews,safety studies,research on new detection methods,and practical applications of sulfites and their additives.In addition,studies on the combination of sulfites with other drugs and the post-marketing safety evaluation of related products have also been carried out in foreign countries.In China,more studies have been conducted on the new applications of sulfites,the detection of sulfites in Chinese herbal medicines,and the setting of standards for the limits of sulfites.Conclusions China's existing research efforts need to be strengthened and the depth is insufficient,resulting in a disconnect between basic safety research and regulation.In the future,strengthening the cooperation between more subjects in China and abroad,broadening the scope of research,proactively introducing risk management research,and strengthening the safety supervision of related products after marketing are effective ways to promote the safety of sulfites and their additives.