尿液代谢组学在前列腺癌中的应用研究进展

Advance in the application of urine metabolomics in prostate cancer

前列腺癌(PCa)是最常见的泌尿系统恶性肿瘤之一,早期诊治可改善患者预后。尿液代谢组学在前列腺癌生物标志物筛选和鉴定等方面具有显著优势。大量文献研究报道了尿液代谢组学在前列腺癌中的应用,并在尿液中筛选发现多种相关代谢标志物。该文将从尿液代谢组学在前列腺癌早期诊断、疾病监测、预后评估,个体化治疗中的应用,以及相关挑战来进行综述。

Prostate cancer(PCa) is one of the most common malignancies in the urinary system,and early diagnosis and treatment can significantly improve patient prognosis.Metabolomics is an essential branch of systems biology,among which urine metabolomics holds remarkable advantages in the identification and screening of biomarkers for prostate cancer.Numerous studies have reported the application of urine metabolomics in prostate cancer,identifying multiple relevant metabolic biomarkers in urine.In this review,we will provide a comprehensive overview of the application and related challenges of urine metabolomics in the early diagnosis,disease monitoring,prognostic evaluation,and personalized therapy in the field of prostate cancer.