二氧化碳点阵激光联合壬二酸乳膏治疗玫瑰痤疮患者的效果

Effects of carbon dioxide lattice laser combined with Azelaic acid cream in treatment of patients with rosacea

目的:观察二氧化碳点阵激光联合壬二酸乳膏治疗玫瑰痤疮患者的效果。方法:回顾性分析2022年11月至2023年1月该院收治的98例玫瑰痤疮患者的临床资料,根据治疗方法不同将其分为对照组和观察组各49例。对照组采用壬二酸乳膏治疗,观察组在对照组基础上联合二氧化碳点阵激光治疗。比较两组临床疗效,治疗前后临床症状(脓疱、丘疹、红斑)评分、炎性因子[可溶性白细胞介素-2受体(SIL-2R)、白细胞介素(IL)-6、IL-37]水平,不良反应发生率和复发率。结果:观察组治疗总有效率为95.92%(47/49),高于对照组的83.67%(41/49),差异有统计学意义(P<0.05);治疗后,两组脓疱、丘疹、红斑等临床症状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IL-6、SIL-2R、IL-37水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);随访1个月,观察组复发率为2.04%(1/49),低于对照组的16.33%(8/49),差异有统计学意义(P<0.05)。结论:二氧化碳点阵激光联合壬二酸乳膏治疗玫瑰痤疮患者,可提高临床疗效,减轻临床症状和炎症反应,降低复发率,效果优于单纯壬二酸乳膏治疗。

Objective:To observe effects of carbon dioxide lattice laser combined with Azelaic acid cream in treatment of patients with rosacea.Methods:The clinical data of 98 patients with rosacea admitted to this hospital from November 2022 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,49 cases in each group.The control group was treated with Azelaic acid cream,while the observation group was treated with carbon dioxide lattice laser on the basis of that of the control group.The clinical efficacy,the clinical symptoms(pustules,papules,erythema)score and the levels of inflammatory factors[soluble interleukin-2 receptor(SIL-2R),interleukin(IL)-6,IL-37]before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 95.92%(47/49),which was higher than 83.67%(41/49)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as pustules,papules and erythema in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,SIL-2R and IL-37 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 1 month of follow-up,the recurrence rate of the observation group was 2.04%(1/49),which was lower than 16.33%(8/49)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Carbon dioxide lattice laser combined with Azelaic acid cream in the treatment of the patients with rosacea can improve the clinical efficacy,reduce the clinical symptoms,reduce the inflammatory response and reduce the recurrence rate.Moreover,it is superior to single Azelaic acid cream treatment.