天然多糖对炎症性肠炎作用的研究进展

Research Progress on the Effects of Natural Polysaccharides on Inflammatory Bowel Diseases

炎症性肠病(IBD)具有持久性和反复性的特点,目前临床治疗药物效果差、价格昂贵且不良反应大,给患者带来长期困扰。天然多糖来源广泛、成本低廉且副作用少,可通过减轻炎症、缓解氧化应激、调整菌群、保护黏膜屏障等多方面治疗IBD。此外,多糖还可作为IBD药物的载体。由于多糖的种类繁多及结构复杂,大部分研究仍停留在动物实验阶段。文章通过探讨天然多糖在治疗IBD中的研究进展,以期为天然多糖的开发利用提供更多依据。

Inflammatory bowel disease(IBD)was characterized by persistence and recurrence.The current clinical treatment drugs were ineffective,expensive,and have serious adverse reactions,which causing long-term distress to patients.Natural polysaccharides have many advantage,such as had a wide range of sources,lower cost,and fewer side effects,which can treat IBD by reducing inflammation,alleviating oxidative stress,adjusting microbial flora,and protecting mucosal barrier.In addition,polysaccharides have been studied as carriers of IBD drugs.However,due to the wide variety and complex structure of polysaccharides,most studies are still in the stage of animal experiments.This current paper mainly discusses the recent research progress of natural polysaccharides in the treatment of IBD,in order to provided more evidences for the further development and utilization of polysaccharides.