超皮秒激光与CO_(2)点阵激光治疗萎缩性痤疮瘢痕的疗效和安全性对照研究

A comparative study on the efficacy and safety of Picoway picosecond laser and fractional CO_(2)laser in the treatment of atrophic acne scars

目的观察并比较超皮秒激光与CO_(2)点阵激光治疗萎缩性痤疮瘢痕的疗效和安全性。方法选择面部萎缩性痤疮瘢痕患者20例,随机选择一侧使用超皮秒激光治疗(试验组),另一侧使用CO_(2)点阵激光治疗(对照组),一共治疗3次,每次间隔一个半月到2个月。治疗前后采用ECCA评分及IGA评价进行疗效评估。调查患者满意度并记录患者在治疗中疼痛程度及不良反应。结果治疗后试验组ECCA权重评分相较于对照组高,P<0.05。试验组与对照组IGA评价瘢痕改善总有效率分别为65%和85%,差异无统计学意义P>0.05。患者对试验组整体满意度为75%,对照组满意度90%。试验组疼痛程度较对照组更低,P<0.05。试验组不良反应较对照组不良反应更少,持续时间更短,安全性更高。结论两种激光均能有效改善萎缩性痤疮瘢痕,但CO_(2)点阵激光治疗的疗效更好;超皮秒激光治疗的疼痛程度及不良反应最少,安全性更高。

Objective To observe and compare the efficacy and safety of Picoway picosecond laser and fractional CO_(2) laser in the treatment of atrophic acne scars.Methods Twenty patients with facial atrophic acne scars were selected,and one side was randomly selected for treatment with ultra picosecond laser(experimental group),while the other side was treated with CO_(2) lattice laser(control group).A total of three treatments were performed,with an interval of one and a half to two months between each treatment.ECCA score and IGA evaluation were used to evaluate the efficacy before and after treatment.Investigate patient satisfaction and record the degree of pain and adverse reactions during treatment.Results After treatment,the ECCA weight score of the experimental group was higher than that of the control group,with P<0.05.The total effective rates of scar improvement evaluated by IGA in the experimental group and the control group were 65% and 85%,respectively,with no statistically significant difference(P>0.05).The overall satisfaction of patients with the experimental group was 75%,while the satisfaction of the control group was 90%.The pain level in the experimental group was lower than that in the control group,P<0.05.The experimental group had fewer adverse reactions,shorter duration,and higher safety compared to the control group.Conclusion Both lasers can effectively improve atrophic acne scars,but the efficacy of fractional CO,laser treatment is better.and the pain degree and adverse reactions of Picoway picosecond laser treatment are least,and the safety is higher.