2940 nm点阵激光联合A型肉毒毒素改善眶周皮肤老化的临床疗效

2940 nm fractional laser combined with botulinum toxin type A Improve the clinical efficaey of periorbital skin aging

目的观察2940 nm点阵激光联合A型肉毒毒素改善眶周皮肤老化的临床疗效。方法将105例求美者随机分为3组:联合治疗组(35例),注射对照组(35例)和激光对照组(35例)。联合治疗组:先采用2940 nm点阵激光治疗1次,两周后采用A型肉毒毒素进行1次注射,间隔2个月再次使用2940 nm点阵激光治疗1次;注射对照组:仅采用A型肉毒毒素进行1次注射;激光对照组仅使用2940nm点阵激光治疗2次,每次间隔2个月。三组均随访26周,由医师及求美者对其静态和动态的眶周皱纹分别进行客观评价及满意度打分。结果采用皱纹严重等级量表(WSRS)统计分析3组求美者眶周皮肤老化均得到改善。面部动态皱纹的治疗效果:注射组4周有效率达到了93.3%,26周降到6.7%;激光组4周有效率为13.3%,26周达到了60%;联合组4周的有效率达到了93.3%,26周达到66.7%。面部静态皱纹的治疗效果:注射组4周有效率达到了73.3%,26周降到3.3%;激光组4周有效率为36.7%,26周达到了73.3%;联合组4周的有效率达到了83.3%,26周达到80%。结论2940nm点阵激光联合A型肉毒素改善眶周皮肤老化,起效快,效果显著,持续时间长,安全可靠,值得推广。

Objective To observe the clinical efficacy of 2940nm lattice laser combined with type A botulinum toxin in improving periorbital skin aging.Methods 105 beauty seekers were randomly divided into three groups:combination therapy group(35 cases),injection control group(35 cases),and laser control group(35 cases).Combination therapy group:First,use 2940nm lattice laser for treatment once,then inject type A botulinum toxin once two weeks later,and use 2940nm lattice laser again every two months for treatment once;Injection control group:Only type A botulinum toxin was injected once;The laser control group was only treated twice with 2940nm lattice laser,with a 2-month interval between each treatment.All three groups were followed up for 26 weeks,and their static and dynamic orbital wrinkles were objectively evaluated and satisfaction scores were given by physicians and beauty seekers,respectively.Results The Wrinkle Severity Scale(WSRS)was used to statistically analyze the aging of the periorbital skin in all three groups of beauty seekers,and the results were improved.The treatment effect of facial dynamic wrinkles:the effective rate of the injection group reached 93.3% after 4 weeks,and decreased to 6.7% after 26 weeks;The effective rate of the laser group was 13.3% after 4 weeks,and reached 60% after 26 weeks;The effectiveness rate of the joint group reached 93.3% in 4 weeks and 66.7% in 26 weeks.The treatment effect of facial static wrinkles:the effective rate of the injection group reached 73.3% after 4 weeks,and decreased to 3.3% after 26 weeks;The effective rate of the laser group was 36.7% at 4 weeks and 73.3% at 26 weeks;The effectiveness rate of the joint group reached 83.3% in 4 weeks and 80% in 26 weeks.Conclusion The combination of 2940nm lattice laser and type A botulinum toxin improves periorbital skin aging,with fast onset,significant effect,long duration,safety and reliability,and is worth promoting.