血浆D-二聚体、纤维蛋白原阳性结果与肺癌患者临床病理特征及预后的关系

Relationship between plasma D-dimer,fibrinogen positive results and clinic pathological features,prognosis of lung cancer patients

目的分析D-二聚体、纤维蛋白原阳性结果与非小细胞肺癌(NSCLC)患者临床病理特征及预后的关系,并探讨临床意义。方法选取2019年1月—2020年12月聊城市第二人民医院收治的318例NSCLC患者作为NSCLC组,选择同时期健康查体者100例作为对照组,进行D-二聚体、纤维蛋白原测定,比较二组D-二聚体、纤维蛋白原结果阳性率的差异;分析血浆D-二聚体、纤维蛋白原阳性结果与患者临床病理特征关系;根据随访情况分析D-二聚体、纤维蛋白原阳性结果与患者预后的关系。结果NSCLC组血浆D-二聚体和纤维蛋白原结果阳性率显著高于对照组,差异有统计学意义(P<0.05);血浆D-二聚体和纤维蛋白原阳性结果与肺癌患者肿瘤大小、淋巴结转移情况以及TNM分期有关(P<0.0.5);D-二聚体和纤维蛋白原结果阳性患者病死率显著高于阴性患者,差异有统计学意义(P<0.05)。结论D-二聚体和纤维蛋白原阳性结果与肺癌患者肿瘤直径≥3cm、淋巴结转移、TNM分期高等临床病理特征有关,与患者预后不良有关;监测D-二聚体、纤维蛋白原可能有助于评估肺癌严重程度及患者预后。

Objective To analyze the relationship between D-dimer,fibrinogen positive results and clinic pathological features and prognosis of non-small cell lung cancer(NSCLC)patients.Methods Three hundred and eighteen NSCLC patients,who were admitted in Liaocheng Second People's Hospital from January 2019 to December 2020,were selected as NSCLC group,and 100 healthy individuals,who underwent physical examination during the same period,were selected as control group.D-dimer and fibrinogen tests were conducted to compare the difference in positive rates of D-dimer and fibrinogen results between the two groups.Analyze relationship between positive results of plasma D-dimer and fibrinogen and clinical pathological characteristics of patients.Analyze relationship between positive results of D-dimer and fibrinogen and the prognosis of patient based on follow-up.Results The positive rates of plasma D-dimer and fibrinogen in NSCLC group were significantly higher than those in control group,with a statistically significant difference(P<0.05).The positive results of plasma D-dimer and fibrinogen were correlated with tumor size,lymph node metastasis,and TNM staging in lung cancer patients(P<0.05).The mortality rate of patients with positive D-dimer and fibrinogen results was significantly higher than that of patients with negative results,and the difference was statistically significant(P<0.05).Conclusion The positive results of D-dimer and fibrinogen were related to the poor clinical and pathological features,such as tumor diameter≥3cm,lymph node metastasis,high TNM stage,and poor prognosis.Monitoring D-dimer and fibrinogen may help evaluate the severity of lung cancer and the prognosis of patients.